2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol
2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol structure
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Common Name | 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol | ||
|---|---|---|---|---|
| CAS Number | 112-60-7 | Molecular Weight | 194.225 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 328.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C8H18O5 | Melting Point | -5.6 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 176.7±0.0 °C | |
Use of 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanolPROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | tetraethylene glycol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | PROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| Related Catalog | |
| Target |
Alkyl/ether |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 328.0±0.0 °C at 760 mmHg |
| Melting Point | -5.6 °C(lit.) |
| Molecular Formula | C8H18O5 |
| Molecular Weight | 194.225 |
| Flash Point | 176.7±0.0 °C |
| Exact Mass | 194.115417 |
| PSA | 68.15000 |
| LogP | -2.23 |
| Vapour density | 6.7 (vs air) |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.455 |
| InChIKey | UWHCKJMYHZGTIT-UHFFFAOYSA-N |
| SMILES | OCCOCCOCCOCCO |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| Water Solubility | soluble |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US) |
|---|---|
| Hazard Codes | C |
| Risk Phrases | 36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | XC2100000 |
| HS Code | 2942000000 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 10 | |
CAS#:107-21-1
CAS#:111-44-4
CAS#:62732-91-6
CAS#:111-90-0
CAS#:111-46-6
CAS#:75-21-8
CAS#:81194-61-8
CAS#:112-26-5
CAS#:106-93-4
CAS#:7388-28-5![2-[2-[2-(2-chloroethoxy)ethoxy]ethoxy]ethoxymethylbenzene structure](https://image.chemsrc.com/caspic/474/105891-51-8.png)
CAS#:105891-51-8
CAS#:10522-26-6
CAS#:1208234-08-5
CAS#:112370-99-7![2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl stearate structure](https://image.chemsrc.com/caspic/088/106-07-0.png)
CAS#:106-07-0
CAS#:33941-15-0
CAS#:57602-02-5
CAS#:39160-70-8
CAS#:33089-37-1
CAS#:71092-61-0This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2909499000 |
|---|---|
| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Preparation and application of sol-gel acrylate and methacrylate solid-phase microextraction fibres for gas chromatographic analysis of organoarsenic compounds.
Anal. Chim. Acta 837 , 52-63, (2014) Novel solid-phase microextraction (SPME) fibres containing methyl, ethyl, butyl acrylate and methacrylate were first prepared by a sol-gel technique and investigated for determination of selected orga... |
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The novel semi-biodegradable interpenetrating polymer networks based on urethane-dimethacrylate and epoxy-polyester components as alternative biomaterials.
Acta Bioeng. Biomech. 17 , 13-22, (2015) This paper presents the pilot study aimed at the development of new full interpenetrating polymer networks based on urethane- dimethacrylate and biodegradable epoxy-polyester as the proposition of new... |
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Sustained release of TGF-β1 from biodegradable microparticles prepared by a new green process in CO2 medium.
Int. J. Pharm. 493 , 357-65, (2015) The aim of this work was to encapsulate transforming growth factor β1 (TGF-β1) into PLGA microparticles for regenerative medicine applications. TGF-β1 was firstly precipitated to ensure its stability ... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 2,2'-[Oxybis(2,1-ethanediyloxy)]diethanol |
| 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol |
| Tetra(ethylene glycol) |
| 2,2'-[Oxybis(ethane-2,1-diyloxy)]diethanol |
| MFCD00002879 |
| Tetraglycol |
| Ethyl acetate |
| Tetraethylene glycol |
| 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol |
| EINECS 203-989-9 |
| Bis[2-(2-hydroxyethoxy)ethyl] ether |
| Bis[2-(2-hydroxyethoxy)ethyl]ether |
| tetraethylene glycol- |
| tetraethyleneglycol |
| PEG-4 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does tetraethylene glycol have? |
| A: English synonyms of tetraethylene glycol: 2,2'-[Oxybis(2,1-ethanediyloxy)]diethanol, 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol, Tetra(ethylene glycol), 2,2'-[Oxybis(ethane-2,1-diyloxy)]diethanol, MFCD00002879, Tetraglycol, Ethyl acetate, Tetraethylene glycol, 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol, EINECS 203-989-9, Bis[2-(2-hydroxyethoxy)ethyl] ether, Bis[2-(2-hydroxyethoxy)ethyl]ether, tetraethylene glycol-, tetraethyleneglycol, PEG-4. |
| Q: What are the uses of tetraethylene glycol? |
| A: Main uses of tetraethylene glycol: PROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| Q: What is the safety information for tetraethylene glycol? |
| A: Safety information for tetraethylene glycol: S24/25. |
| Q: What is the LogP of tetraethylene glycol? |
| A: LogP of tetraethylene glycol is -2.23. |
| Q: What are the downstream products of tetraethylene glycol? |
| A: Related downstream products(CAS) of tetraethylene glycol: 105891-51-8;10522-26-6;1208234-08-5;112370-99-7;106-07-0;33941-15-0;57602-02-5;39160-70-8;33089-37-1;71092-61-0. |
| Q: What is the boiling point of tetraethylene glycol? |
| A: Boiling point of tetraethylene glycol is 328.0±0.0 °C at 760 mmHg. |
| Q: What are the upstream materials of tetraethylene glycol? |
| A: Related upstream materials(CAS) of tetraethylene glycol: 107-21-1;111-44-4;62732-91-6;111-90-0;111-46-6;75-21-8;81194-61-8;112-26-5;106-93-4;7388-28-5. |
| Q: What is the molecular weight of tetraethylene glycol? |
| A: Molecular weight of tetraethylene glycol is 194.225. |
| Q: What is the SMILES notation of tetraethylene glycol? |
| A: SMILES notation of tetraethylene glycol is OCCOCCOCCOCCO. |
| Q: How is the water solubility of tetraethylene glycol? |
| A: Water solubility of tetraethylene glycol: soluble. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |