2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol

Modify Date: 2024-01-02 16:05:15

2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol Structure
2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol structure
 Common Name 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol
CAS Number 112-60-7 Molecular Weight 194.225
Density 1.1±0.1 g/cm3 Boiling Point 328.0±0.0 °C at 760 mmHg
Molecular Formula C8H18O5 Melting Point -5.6 °C(lit.)
MSDS Chinese USA Flash Point 176.7±0.0 °C

 Use of 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol


PROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

 Names

Name tetraethylene glycol
Synonym More Synonyms

  Biological Activity

Description PROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

Alkyl/ether

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 328.0±0.0 °C at 760 mmHg
Melting Point -5.6 °C(lit.)
Molecular Formula C8H18O5
Molecular Weight 194.225
Flash Point 176.7±0.0 °C
Exact Mass 194.115417
PSA 68.15000
LogP -2.23
Vapour density 6.7 (vs air)
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.455
Stability Stable. Incompatible with strong oxidizing agents, strong bases.
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XC2100000
CHEMICAL NAME :
Tetraethylene glycol
CAS REGISTRY NUMBER :
112-60-7
BEILSTEIN REFERENCE NO. :
1634320
LAST UPDATED :
199712
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C8-H18-O5
MOLECULAR WEIGHT :
194.26
WISWESSER LINE NOTATION :
Q2O2O2O2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28900 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
REFERENCE :
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0987-0693 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84662 No. of Facilities: 206 (estimated) No. of Industries: 7 No. of Occupations: 12 No. of Employees: 1685 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84662 No. of Facilities: 3704 (estimated) No. of Industries: 40 No. of Occupations: 44 No. of Employees: 55282 (estimated) No. of Female Employees: 1585 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes C
Risk Phrases 36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS XC2100000
HS Code 2942000000

 Synthetic Route

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

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 Synonyms

2,2'-[Oxybis(2,1-ethanediyloxy)]diethanol
2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol
Tetra(ethylene glycol)
2,2'-[Oxybis(ethane-2,1-diyloxy)]diethanol
MFCD00002879
Tetraglycol
Ethyl acetate
Tetraethylene glycol
2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol
EINECS 203-989-9
Bis[2-(2-hydroxyethoxy)ethyl] ether
Bis[2-(2-hydroxyethoxy)ethyl]ether
tetraethylene glycol-
tetraethyleneglycol
Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-
PEG-4
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Chemsrc provides CAS#:112-60-7 MSDS, density, melting point, boiling point, structure, etc. Its name is 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol>> amp version: 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol

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