Bromo-PEG4-bromide

Modify Date: 2024-01-06 17:42:03

Bromo-PEG4-bromide structure	Common Name	Bromo-PEG4-bromide
	CAS Number	57602-02-5	Molecular Weight	364.071
	Density	1.5±0.1 g/cm3	Boiling Point	373.2±32.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₂₀Br₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	152.9±23.6 °C

Use of Bromo-PEG4-bromide

Bromo-PEG4-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	1,14-Dibromo-3,6,9,12-tetraoxatetradecane
Synonym	More Synonyms

Description	Bromo-PEG4-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Mulyana Y, et al. Oligonuclear polypyridylruthenium(II) complexes incorporating flexible polar and non-polar bridges: synthesis, DNA-binding and cytotoxicity. Dalton Trans. 2011 Feb 21;40(7):1510-23. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	1.5±0.1 g/cm3
Boiling Point	373.2±32.0 °C at 760 mmHg
Molecular Formula	C₁₀H₂₀Br₂O₄
Molecular Weight	364.071
Flash Point	152.9±23.6 °C
Exact Mass	361.972809
PSA	36.92000
LogP	0.80
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.489

Hazard Codes	Xi
HS Code	2909199090

Pentaethylene glycol

CAS#:4792-15-8

~86%

Bromo-PEG4-bromide

CAS#:57602-02-5

Literature: Biron, Eric; Otis, Francois; Meillon, Jean-Christophe; Robitaille, Martin; Lamothe, Julie; Van Hove, Patrick; Cormier, Marie-Eve; Voyer, Normand Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1279 - 1290

Pentaethylene G...

CAS#:109789-39-1

Bromo-PEG4-bromide

CAS#:57602-02-5

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 3 p. 557 - 560 Steroids, , vol. 71, # 10 p. 911 - 921

Ms-PEG4-Ms

CAS#:55400-73-2

Bromo-PEG4-bromide

CAS#:57602-02-5

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 2 p. 636 - 643

Chloro-PEG5-chloride

CAS#:5197-65-9

Bromo-PEG4-bromide

CAS#:57602-02-5

Literature: Canadian Journal of Chemistry, , vol. 66, p. 1097 - 1108

2,2'-((Oxybis(e...

CAS#:112-60-7

Bromo-PEG4-bromide

CAS#:57602-02-5

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 2 p. 636 - 643

Precursor 5
CAS#:4792-15-8 Pentaethylene glycol CAS#:109789-39-1 Pentaethylene G... CAS#:55400-73-2 Ms-PEG4-Ms CAS#:5197-65-9 Chloro-PEG5-chloride
CAS#:112-60-7 2,2'-((Oxybis(e...
DownStream 2
CAS#:212262-08-3 3,6,9,12-tetrao... CAS#:89141-20-8 2-[2-[2-[2-(2-s...

HS Code	2909199090
Summary	2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%