BRL 52537 HYDROCHLORIDE

Modify Date: 2024-03-05 11:29:54

BRL 52537 HYDROCHLORIDE Structure
BRL 52537 HYDROCHLORIDE structure
Common Name BRL 52537 HYDROCHLORIDE
CAS Number 112282-24-3 Molecular Weight 391.76
Density N/A Boiling Point N/A
Molecular Formula C18H25Cl3N2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BRL 52537 HYDROCHLORIDE


BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with Kis of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage[1].

 Names

Name BRL 52537 hydrochloride
Synonym More Synonyms

 BRL 52537 HYDROCHLORIDE Biological Activity

Description BRL 52537 hydrochloride is a highly selective κ-Opioid receptor (KOR) agonist with Kis of 0.24 nM and 1560 nM for κ and μ subtypes, respectively. BRL 52537 hydrochloride decreases ischemia-evoked NO production as a potential mechanism of neuroprotection. BRL 52537 hydrochloride attenuates early stroke damage[1].
Related Catalog
Target

Ki: 0.24 nM (κ-Opioid receptor) and 1560 nM (μ-Opioid receptor)[1]

References

[1]. Toru Goyagi, et al. Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats. Stroke. 2003 Jun;34(6):1533-8.  

 Chemical & Physical Properties

Molecular Formula C18H25Cl3N2O
Molecular Weight 391.76
Exact Mass 390.103241
PSA 23.55000
LogP 4.69060
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi

 Synonyms

(±)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride
Ethanone, 2-(3,4-dichlorophenyl)-1-[2-(1-pyrrolidinylmethyl)-1-piperidinyl]-, hydrochloride (1:1)
2-(3,4-Dichlorophenyl)-1-[2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone hydrochloride (1:1)
2-(3,4-Dichlorophenyl)-1-[2-(1-pyrrolidinylmethyl)-1-piperidinyl]ethanone hydrochloride (1:1)
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