4-Nitropyridine N-oxide

Modify Date: 2026-07-01 12:09:09

4-Nitropyridine N-oxide Structure
4-Nitropyridine N-oxide structure
 Common Name 4-Nitropyridine N-oxide
CAS Number 1124-33-0 Molecular Weight 140.09700
Density 1.43 g/cm3 Boiling Point 397.2ºC at 760 mmHg
Molecular Formula C5H4N2O3 Melting Point 159-162 °C(lit.)
MSDS Chinese USA Flash Point 194ºC
Symbol GHS06
GHS06		 Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 4-Nitropyridine N-oxide
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.43 g/cm3
Boiling Point 397.2ºC at 760 mmHg
Melting Point 159-162 °C(lit.)
Molecular Formula C5H4N2O3
Molecular Weight 140.09700
Flash Point 194ºC
Exact Mass 140.02200
PSA 71.28000
LogP 1.54650
InChIKey RXKNNAKAVAHBNK-UHFFFAOYSA-N
SMILES O=[N+]([O-])c1cc[n+]([O-])cc1
Water Solubility insoluble

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT6380000
CHEMICAL NAME :
Pyridine, 4-nitro-, 1-oxide
CAS REGISTRY NUMBER :
1124-33-0
LAST UPDATED :
199710
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C5-H4-N2-O3
MOLECULAR WEIGHT :
140.11
WISWESSER LINE NOTATION :
T6NJ AO DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
107 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
3916 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
7208 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
960 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - hamster Cells - not otherwise specified
DOSE/DURATION :
50 umol/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 229,416,1971

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H315-H319-H335
Precautionary Statements P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic
Risk Phrases R25;R36/37/38;R40
Safety Phrases S26-S45-S37/39-S28A
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS UT6380000
Packaging Group III
Hazard Class 6.1
HS Code 29333999

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

1-oxidopyridin-1-ium,hydrochloride structure

1-oxidopyridin-...

CAS#:16527-88-1

~%

4-Nitropyridine N-oxide Structure

4-Nitropyridine...

CAS#:1124-33-0

Learn More
Literature: WO2011/108009 A2, ; Page/Page column 13 ;
pyridine oxide structure

pyridine oxide

CAS#:694-59-7

~%

Pyridine, 2-nitro structure

Pyridine, 2-nitro

CAS#:15009-91-3

4-Nitropyridine N-oxide Structure

4-Nitropyridine...

CAS#:1124-33-0

Learn More
Literature: Journal of Organic Chemistry, , vol. 18, p. 534,541
4-Nitropyridine structure

4-Nitropyridine

CAS#:1122-61-8

~%

4-Nitropyridine N-oxide Structure

4-Nitropyridine...

CAS#:1124-33-0

Learn More
Literature: Tetrahedron, , vol. 37, p. 1871 - 1873
(H2O)5 chromium(III)(4-NO2-pyridine-N-oxide) structure

(H2O)5 chromium...

CAS#:933761-82-1

~%

4-Nitropyridine N-oxide Structure

4-Nitropyridine...

CAS#:1124-33-0

N/A structure

N/A

CAS#:14873-01-9

Learn More
Literature: European Journal of Inorganic Chemistry, , # 14 p. 2894 - 2899
pyridine oxide structure

pyridine oxide

CAS#:694-59-7

~77%

4-Nitropyridine N-oxide Structure

4-Nitropyridine...

CAS#:1124-33-0

Learn More
Literature: Taghavi-Moghadam, Shahriyar; Kleemann, Axel; Golbig, Klaus Georg Organic Process Research and Development, 2001 , vol. 5, # 6 p. 652 - 658
structure

CAS#:120309-62-8

~%

4-Nitropyridine N-oxide Structure

4-Nitropyridine...

CAS#:1124-33-0

Heptakis(2,6-di-O-methyl)-b-cyclodextrin structure

Heptakis(2,6-di...

CAS#:51166-71-3

Learn More
Literature: Chemical & Pharmaceutical Bulletin, , vol. 36, # 10 p. 3753 - 3759
pyridine oxide structure

pyridine oxide

CAS#:694-59-7

Sulfuric acid structure

Sulfuric acid

CAS#:7664-93-9

nitric acid structure

nitric acid

CAS#:7697-37-2

~%

4-Nitropyridine structure

4-Nitropyridine

CAS#:1122-61-8

Detail Learn More
Literature: Journal of Organic Chemistry, , vol. 18, p. 534,541

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles14

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Pseudomonas aeruginosa Biofilm Formation and Persistence, along with the Production of Quorum Sensing-Dependent Virulence Factors, Are Disrupted by a Triterpenoid Coumarate Ester Isolated from Dalbergia trichocarpa, a Tropical Legume.

PLoS ONE 10 , e0132791, (2015)

Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in...

At a supra-physiological concentration, human sexual hormones act as quorum-sensing inhibitors.

PLoS ONE 8(12) , e83564, (2013)

N-acylhomoserine lactone (AHL)-mediated quorum-sensing (QS) regulates virulence functions in plant and animal pathogens such as Agrobacterium tumefaciens and Pseudomonas aeruginosa. A chemolibrary of ...

Facile one-pot direct arylation and alkylation of nitropyridine N-oxides with Grignard reagents.

Org. Lett. 13(22) , 6102-5, (2011)

Facile arylation and alkylation of nitropyridine N-oxides were developed through the reactions of Grignard reagents with nitropyridine N-oxides. For the same 4-nitropyridine N-oxide, arylation occurre...

 4-Nitropyridine N-oxideBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: qHTS ...
Source: 824
Target: N/A
External Id: P53MS837
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
Name: Inhibition of quorum sensing system in Chromobacterium violaceum ATCC 31532 assessed ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4813325
Name: Inhibition of quorum sensing system lasB in Pseudomonas aeruginosa transfected with l...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4813324
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

4-Nitropyridine N-ox
4-Nitropyridine oxide
4-NITRO-N-OXOPYRIDINE
4-nitraminopyridine N-oxide
wellno604aa
Avitrol 100
4-Nitropyridine N-Oxide
MFCD00006206
4-nitropyridine-N-oxide
4-Nitropyridine 1-oxide
EINECS 214-395-4
4-nitropyridine-1-oxide

 4-Nitropyridine N-oxide | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of 4-Nitropyridine N-oxide?
A: Boiling point of 4-Nitropyridine N-oxide is 397.2ºC at 760 mmHg.
Q: What is the polar surface area (PSA) of 4-Nitropyridine N-oxide?
A: Polar surface area (PSA) of 4-Nitropyridine N-oxide is 71.28000.
Q: What is the safety information for 4-Nitropyridine N-oxide?
A: Safety information for 4-Nitropyridine N-oxide: S26-S45-S37/39-S28A.
Q: What is the molecular weight of 4-Nitropyridine N-oxide?
A: Molecular weight of 4-Nitropyridine N-oxide is 140.09700.
Q: What is the English name of 4-Nitropyridine N-oxide?
A: The English name of 4-Nitropyridine N-oxide is 4-Nitropyridine N-oxide.
Q: What English synonyms does 4-Nitropyridine N-oxide have?
A: English synonyms of 4-Nitropyridine N-oxide: 4-Nitropyridine N-ox, 4-Nitropyridine oxide, 4-NITRO-N-OXOPYRIDINE, 4-nitraminopyridine N-oxide, wellno604aa, Avitrol 100, 4-Nitropyridine N-Oxide, MFCD00006206, 4-nitropyridine-N-oxide, 4-Nitropyridine 1-oxide, EINECS 214-395-4, 4-nitropyridine-1-oxide.
Q: What is the CAS number of 4-Nitropyridine N-oxide?
A: CAS number of 4-Nitropyridine N-oxide is 1124-33-0.
Q: How is the water solubility of 4-Nitropyridine N-oxide?
A: Water solubility of 4-Nitropyridine N-oxide: insoluble.
Q: What are the upstream materials of 4-Nitropyridine N-oxide?
A: Related upstream materials(CAS) of 4-Nitropyridine N-oxide: 694-59-7;16527-88-1;1122-61-8;120309-62-8;7664-93-9;7697-37-2.
Q: What is the SMILES notation of 4-Nitropyridine N-oxide?
A: SMILES notation of 4-Nitropyridine N-oxide is O=[N+]([O-])c1cc[n+]([O-])cc1.

 4-Nitropyridine N-oxidefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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Chemsrc provides 4-Nitropyridine N-oxide(CAS#:1124-33-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 4-Nitropyridine N-oxide are included as well.>> amp version: 4-Nitropyridine N-oxide

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