4-Nitropyridine N-oxide
4-Nitropyridine N-oxide structure
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Common Name | 4-Nitropyridine N-oxide | ||
|---|---|---|---|---|
| CAS Number | 1124-33-0 | Molecular Weight | 140.09700 | |
| Density | 1.43 g/cm3 | Boiling Point | 397.2ºC at 760 mmHg | |
| Molecular Formula | C5H4N2O3 | Melting Point | 159-162 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 194ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Pseudomonas aeruginosa Biofilm Formation and Persistence, along with the Production of Quorum Sensing-Dependent Virulence Factors, Are Disrupted by a Triterpenoid Coumarate Ester Isolated from Dalbergia trichocarpa, a Tropical Legume.
PLoS ONE 10 , e0132791, (2015) Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in biofilm formation. One of the active compounds has been is... |
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At a supra-physiological concentration, human sexual hormones act as quorum-sensing inhibitors.
PLoS ONE 8(12) , e83564, (2013) N-acylhomoserine lactone (AHL)-mediated quorum-sensing (QS) regulates virulence functions in plant and animal pathogens such as Agrobacterium tumefaciens and Pseudomonas aeruginosa. A chemolibrary of more than 3500 compounds was screened using two bacterial A... |
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Facile one-pot direct arylation and alkylation of nitropyridine N-oxides with Grignard reagents.
Org. Lett. 13(22) , 6102-5, (2011) Facile arylation and alkylation of nitropyridine N-oxides were developed through the reactions of Grignard reagents with nitropyridine N-oxides. For the same 4-nitropyridine N-oxide, arylation occurred at the 2- (or 6-) position, whereas alkylation occurred a... |
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DNA double-strand break repair in parental chromatin of mouse zygotes, the first cell cycle as an origin of de novo mutation.
Hum. Mol. Genet. 17(13) , 1922-37, (2008) In the human, the contribution of the sexes to the genetic load is dissimilar. Especially for point mutations, expanded simple tandem repeats and structural chromosome mutations, the contribution of the male germline is dominant. Far less is known about the m... |
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Well-known quorum sensing inhibitors do not affect bacterial quorum sensing-regulated bean sprout spoilage.
J. Appl. Microbiol. 102(3) , 826-37, (2007) To investigate the potential of quorum sensing inhibitors (QSI) as food preservative agents in a food product, where bacterial spoilage is controlled by quorum sensing (QS).The effects of well-known QSI were tested on spoilage phenotypes and on QS-regulated g... |
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Reduced bacterial deposition and attachment by quorum-sensing inhibitor 4-nitro-pyridine-N-oxide: the role of physicochemical effects.
Langmuir 26(14) , 12089-94, (2010) Surface-attached chemical groups that resist protein adhesion are commonly characterized as being hydrophilic, H-bond acceptors, non-H-bond donors, and electrically neutral. Quorum-sensing (QS) inhibitor 4-nitropyridine-N-oxide (4-NPO) that previously was fou... |
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Nitroreductase activity of heart lipoamide dehydrogenase.
Biochem. J. 242(2) , 447-52, (1987) A novel reaction catalysed by lipoamide dehydrogenase is described. In the presence of NADH, lipoamide dehydrogenase reduces the nitro group of 4-nitropyridine and 4-nitropyridine N-oxide. The elution profiles from a DEAE-cellulose column for the dehydrogenas... |
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Carcinogenicity and mutagenicity of 4-nitropyridine 1-oxide derivatives.
Gann 70(6) , 799-806, (1979) Carcinogenicity and mutagenicity of 4-nitropyridine 1-oxide (4-NPO) and 7 kinds of its alkyl derivatives were tested on mice and on Salmonella typhimurium strains and Escherichia coli strains. 3-Methyl-4-NPO is the most potent carcinogen, followed by 3-ethyl-... |
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A characterization study on 2,6-dimethyl-4-nitropyridine N-oxide by density functional theory calculations.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 81(1) , 104-10, (2011) This study deals with the identification of a title compound, 2,6-dimethyl-4-nitropyridine N-oxide by means of theoretical calculations. The optimized molecular structures, vibrational frequencies, corresponding vibrational assignments, thermodynamic properti... |
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Nitroarene reduction and generation of free radicals by cell-free extracts of wild-type, and nitroreductase-deficient and -enriched Salmonella typhimurium strains used in the umu gene induction assay.
Toxicol. Appl. Pharmacol. 154(2) , 126-34, (1999) Studies of the enzymatic properties of cell-free extracts prepared from overnight cultures of the normal, and nitroreductase-deficient and -enriched strains of Salmonella typhimurium, designed for use in the umu gene induction assay of Oda et al. (1992), were... |