Argipressin

Modify Date: 2024-01-02 20:17:58

Argipressin Structure
Argipressin structure
Common Name Argipressin
CAS Number 113-79-1 Molecular Weight 1084.232
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C46H65N15O12S2 Melting Point N/A
MSDS Chinese USA Flash Point 113℃
Symbol GHS07
GHS07
Signal Word Warning

 Use of Argipressin


Argipressin binds to the V1-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells. Sequence: CysTyrPheGlnAsnCysProArgGly-NH2(Disulfide bridge: Cys1-Cys6).

 Names

Name Arginine Vasopressin
Synonym More Synonyms

 Argipressin Biological Activity

Description Argipressin binds to the V1-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells. Sequence: CysTyrPheGlnAsnCysProArgGly-NH2(Disulfide bridge: Cys1-Cys6).
Related Catalog
In Vitro Argipressin binds to the vascular arginine vasopressin receptor, V1, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells. It also stimulates the intracellular release of calcium in A7r5 cells (EC50=5 nM)[1]. AVP-induced [Ca2+]i signals and immunized activity against S-100 in DRG cell culture. The minimum effective concentrations of Argipressin causing [Ca2+]i responses are 100 pM in non-neuronal cells in DRG culture[2].
References

[1]. Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56.

[2]. Moriya T, et al. Vasopressin-induced intracellular Ca²⁺ concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Molecular Formula C46H65N15O12S2
Molecular Weight 1084.232
Flash Point 113℃
Exact Mass 1083.437866
PSA 512.03000
LogP -5.99
Index of Refraction 1.724
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H332
Precautionary Statements P261
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R20
Safety Phrases 36
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles123

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In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3' poly(A) tail of ...

Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function.

PLoS ONE 10 , e0128881, (2015)

Increased blood glucose concentrations promote reactions between glucose and proteins to form advanced glycation end-products (AGE). Circulating AGE in the blood plasma can activate the receptor for a...

GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time.

Proc. Natl. Acad. Sci. U. S. A. 112 , E3920-9, (2015)

The mammalian suprachiasmatic nucleus (SCN) forms not only the master circadian clock but also a seasonal clock. This neural network of ∼10,000 circadian oscillators encodes season-dependent day-lengt...

 Synonyms

EINECS 204-035-4
MFCD00133939
Argipressine
[Arg8]-Vasopressin (AVP)
CYS-TYR-PHE-GLN-ASN-CYS-PRO-ARG-GLY-NH2
Argipressin Acetate
Argipressin
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