A3AR antagonist 2

Modify Date: 2024-04-01 16:31:29

A3AR antagonist 2 structure	Common Name	A3AR antagonist 2
	CAS Number	1144161-05-6	Molecular Weight	412.40100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₁₆N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of A3AR antagonist 2

A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an Ki value of 4.54 nM[1].

Name	N-[2-(4-Methoxyphenyl)-1-oxo-1,2-dihydropyrido[2,3-e][1,2,4]triaz olo[4,3-a]pyrazin-4-yl]benzamide

Description	A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an Ki value of 4.54 nM[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	hA3:4.54 nM (Ki)
References	[1]. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand?Receptor Modeling StudiesJ. Med. Chem., 2009, 52 (8), pp 2407-2419 [2]. Vittoria Colotta, et al. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies. J. Med. Chem. 2009, 52, 8, 2407-2419.

Molecular Formula	C₂₂H₁₆N₆O₃
Molecular Weight	412.40100
Exact Mass	412.12800
PSA	106.90000
LogP	3.07330

4-amino-2-(4-me...

CAS#:1144160-95-1

Benzoyl chloride

CAS#:98-88-4

~88%

A3AR antagonist 2

CAS#:1144161-05-6

Literature: Colotta, Vittoria; Lenzi, Ombretta; Catarzi, Daniela; Varano, Flavia; Filacchioni, Guido; Martini, Claudia; Trincavelli, Letizia; Ciampi, Osele; Pugliese, Anna Maria; Traini, Chiara; Pedata, Felicita; Morizzo, Erika; Moro, Stefano Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2407 - 2419

Precursor 2
CAS#:1144160-95-1 4-amino-2-(4-me... CAS#:98-88-4 Benzoyl chloride
DownStream 0

A3AR antagonist 2

Use of A3AR antagonist 2

Names

A3AR antagonist 2 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream