(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine

Modify Date: 2024-01-23 12:16:46

(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine Structure
(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine structure
Common Name (2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine
CAS Number 114676-67-4 Molecular Weight 331.52300
Density N/A Boiling Point N/A
Molecular Formula C16H33NO4Si Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name 2-Methyl-2-propanyl (2S,4R)-4-{[dimethyl(2-methyl-2-propanyl)sily l]oxy}-2-(hydroxymethyl)-1-pyrrolidinecarboxylate
Synonym More Synonyms

 Chemical & Physical Properties

Molecular Formula C16H33NO4Si
Molecular Weight 331.52300
Exact Mass 331.21800
PSA 59.00000
LogP 3.31640

 Synthetic Route

~95%

(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine Structure

(2S,4R)-1-Boc-4...

CAS#:114676-67-4

Literature: Elsohly, Adel M.; Wespe, Daniel A.; Poore, Tyler J.; Snyder, Scott A. Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5789 - 5794 Angew. Chem., 2013 , vol. 125, # 22 p. 5901 - 5906,7

~93%

(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine Structure

(2S,4R)-1-Boc-4...

CAS#:114676-67-4

Literature: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. Patent: WO2004/76407 A2, 2004 ; Location in patent: Page 27-29 ; WO 2004/076407 A2

~%

(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine Structure

(2S,4R)-1-Boc-4...

CAS#:114676-67-4

Literature: Fujisawa Pharmaceutical Co., Ltd. Patent: US4822787 A1, 1989 ;

~%

(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine Structure

(2S,4R)-1-Boc-4...

CAS#:114676-67-4

Literature: ROTTAPHARM S.P.A.; STASI, Luigi, Piero; ROVATI, Lucio Patent: WO2011/6960 A1, 2011 ; WO 2011/006960 A1

~%

(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine Structure

(2S,4R)-1-Boc-4...

CAS#:114676-67-4

Literature: ROTTAPHARM S.P.A.; STASI, Luigi, Piero; ROVATI, Lucio Patent: WO2011/6960 A1, 2011 ; WO 2011/006960 A1

~%

(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine Structure

(2S,4R)-1-Boc-4...

CAS#:114676-67-4

Literature: Fransson, Rebecca; McCracken, Alison N.; Chen, Bin; McMonigle, Ryan J.; Edinger, Aimee L.; Hanessian, Stephen ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 10 p. 969 - 973

~%

(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine Structure

(2S,4R)-1-Boc-4...

CAS#:114676-67-4

Literature: Zheng, Bo; Wang, Hui; Han, Yong; Liu, Changlu; Peng, Yungui Chemical Communications, 2013 , vol. 49, # 40 p. 4561 - 4563

~%

(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine Structure

(2S,4R)-1-Boc-4...

CAS#:114676-67-4

Literature: Zheng, Bo; Wang, Hui; Han, Yong; Liu, Changlu; Peng, Yungui Chemical Communications, 2013 , vol. 49, # 40 p. 4561 - 4563

~%

(2S,4R)-1-Boc-4-(tert-butyldimethylsilyloxy)-2-(hydroxyMethyl)pyrrolidine Structure

(2S,4R)-1-Boc-4...

CAS#:114676-67-4

Literature: Elsohly, Adel M.; Wespe, Daniel A.; Poore, Tyler J.; Snyder, Scott A. Angewandte Chemie - International Edition, 2013 , vol. 52, # 22 p. 5789 - 5794 Angew. Chem., 2013 , vol. 125, # 22 p. 5901 - 5906,7

 Synonyms

Simvastatin Acid Ammonium Salt
simvastatin hydroxy acid,ammonium salt
Simvastatin acid ammonium
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