Boc-Hyp-OH

Modify Date: 2025-08-20 18:40:33

Boc-Hyp-OH structure	Common Name	Boc-Hyp-OH
	CAS Number	13726-69-7	Molecular Weight	231.246
	Density	1.3±0.1 g/cm3	Boiling Point	390.9±42.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₇NO₅	Melting Point	123-127 °C(lit.)
	MSDS	USA	Flash Point	190.2±27.9 °C

Use of Boc-Hyp-OH

Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]

Name	Boc-L-Hydroxyproline
Synonym	More Synonyms

Description	Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.3±0.1 g/cm3
Boiling Point	390.9±42.0 °C at 760 mmHg
Melting Point	123-127 °C(lit.)
Molecular Formula	C₁₀H₁₇NO₅
Molecular Weight	231.246
Flash Point	190.2±27.9 °C
Exact Mass	231.110672
PSA	87.07000
LogP	-0.71
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.531
Storage condition	-20°C

Boc-Hyp-OH MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

Precursor 10
CAS#:24424-99-5 Di-tert-butyl d... CAS#:51-35-4 L-Hydroxyproline CAS#:34619-03-9 Di-tert-butyl c... CAS#:184046-78-4 (2S,3S)-1-(TERT...
CAS#:74844-91-0 Boc-Hyp-OMe CAS#:7732-18-5 Water CAS#:3236-56-4 dipercarbonate ... CAS#:115352-39-1 (2R)-1-benzylox...
CAS#:84348-37-8 N-Boc-4-oxo-L-p... CAS#:87691-27-8 N-BOC-cis-4-Hyd...
DownStream 10
CAS#:364750-80-1 (4R)-1-(tert-Bu... CAS#:148017-43-0 (2S,4S)-tert-bu... CAS#:148017-44-1 (2S,4S)-tert-bu... CAS#:148017-42-9 1-Pyrrolidineca...
CAS#:40216-83-9 H-Hyp-OMe hydro... CAS#:51-35-4 L-Hydroxyproline CAS#:51154-06-4 (S)-1-(tert-But... CAS#:202477-59-6 (2S,4R)-1-(TERT...
CAS#:83623-78-3 (2S,4S)-4-BENZY... CAS#:84348-37-8 N-Boc-4-oxo-L-p...

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S)-

trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline

BOC-HYP-OH

N-ter

trans-Boc-Hyp-OH

BOC-L-HYP-OH

BOC-HYP

N-BOC-L-Hydroxyproline

RARECHEM EM WB 0136

trans-N-tert-Butoxycarbonyl-4-hydroxy-l-proline

BOC-L-4-HYDROXYPROLINE

BOC-trans-4-hydroxy-L-proline

BOC-TRANS-HYP-OH

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4R)-

(2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

MFCD00053370

trans-N-Boc-4-hydroxy-L-proline

BOC-HYDROXYPROLINE

(4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline

4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline

1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Boc-Hyp-OH
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Sichuan Hengkang Science and Technology Development Co.,Ltd.
China
Product Name: Boc-L-Hydroxyproline cas：13726-69-7
Price: ￥Inquiry/1kg ￥Inquiry/1ton
Purity: 99.0%
Delivery: Inquiry
Contact: Teresa
Email: hk999@hengkangtech.com

GL Biochem (Shanghai) Ltd.
China
Product Name: Boc-Hyp-OH
Price: ￥Inquiry/1kg ￥Inquiry/100g
Purity: 99.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Boc-Hyp-OH
Price: ￥1998.0/1kg ￥278.0/100g ￥98.0/25g ￥1998.0/1kg
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

Chengdu Pukang Biotechnology Co., Ltd.
China
Product Name: Boc-Hyp-OH
Price: ￥Inquiry/10g
Purity: 98.0%
Delivery: Inquiry
Contact: Lihua Yang
Email: sales@pu-kang.com

DC Chemicals Limited
China
Product Name: Boc-Hyp-OH
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Nanjing Peptide Biotech Ltd
China
Product Name: Boc-Hyp-OH
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Delivery: 7 Day
Contact: jom
Email: chenglong.fan@njpeptide.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Boc-Hyp-OH
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥37/1g

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Boc-Hyp-OH

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.