J-147

Modify Date: 2024-01-02 14:08:50

J-147 structure	Common Name	J-147
	CAS Number	1146963-51-0	Molecular Weight	350.335
	Density	1.2±0.1 g/cm3	Boiling Point	412.8±55.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₇F₃N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	203.5±31.5 °C

Use of J-147

J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).IC50 value: 60-115 nM in vitro assay [1]Target: J-147 has been shown to promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06 – 0.115 μM) when applied to cell exposed to the mitochondrial neurotoxin, iodoacetic acid (IAA), toxicity mediated by the excitatory amino acid glutamate, which causes HT22 cell death by an oxytosis mechanism. In the preclinical in vitro development assays, the EC50 value for J-147-induced cell survival is 25 nM. J-147 was metabolically unstable (highly metabolized) with only 12% of parent remaining after incubation with rat microsomes (phase 1 metabolism).

Name	j 147
Synonym	More Synonyms

Description	J-147 is a broad spectrum neuroprotective phenyl hydrazide compound(EC50=60-115 nM) with significant neurotrophic properties related to the induction of brain-derived neurotrophic factor (BDNF).IC50 value: 60-115 nM in vitro assay [1]Target: J-147 has been shown to promotes HT22 and primary cell survival in a dose-dependent manner (EC50 value range of 0.06 – 0.115 μM) when applied to cell exposed to the mitochondrial neurotoxin, iodoacetic acid (IAA), toxicity mediated by the excitatory amino acid glutamate, which causes HT22 cell death by an oxytosis mechanism. In the preclinical in vitro development assays, the EC50 value for J-147-induced cell survival is 25 nM. J-147 was metabolically unstable (highly metabolized) with only 12% of parent remaining after incubation with rat microsomes (phase 1 metabolism).
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Lapchak PA, et al. J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox^TM Safety and Genotoxicity Analysis. J Neurol Neurophysiol. 2013 Aug;4(3). pii: 158.

Density	1.2±0.1 g/cm3
Boiling Point	412.8±55.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₇F₃N₂O₂
Molecular Weight	350.335
Flash Point	203.5±31.5 °C
Exact Mass	350.124207
PSA	41.90000
LogP	5.61
Appearance of Characters	light yellow solid
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.515
Storage condition	-20℃