Aurora A Inhibitor I

Modify Date: 2024-01-22 17:14:42

Aurora A Inhibitor I structure	Common Name	Aurora A Inhibitor I
	CAS Number	1158838-45-9	Molecular Weight	588.075
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₁ClFN₇O₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Aurora A Inhibitor I

Aurora A inhibitor I is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM.

Name	N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]benzamide
Synonym	More Synonyms

Description	Aurora A inhibitor I is a potent and highly selective Aurora A inhibitor with with an IC50 of 3.4 nM.
Related Catalog	Research Areas >> Cancer
Target	Aurora A:3.4 nM (IC50) Aurora B:3.4 μM (IC50)
In Vitro	Aurora A inhibitor I is exceptionally selective Aurora A inhibitors. Aurora A inhibitor I is an useful tool compounds for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B[1].
References	[1]. Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J, Moffat J, Phillips G, Pulk R, Rawson TE, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhu BY, Cochran AG.A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.J Med Chem. 2009 May 28;52(10):3300-7.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	22
RIDADR	NONH for all modes of transport

1-Ethylpiperazine

CAS#:5308-25-8

2-(4-(4-(4-(2-c...

CAS#:1158838-42-6

~80%

Aurora A Inhibitor I

CAS#:1158838-45-9

Precursor 2
CAS#:5308-25-8 1-Ethylpiperazine CAS#:1158838-42-6 2-(4-(4-(4-(2-c...
DownStream 0

Aurora-A Inhibitor I

N-(2-Chlorophenyl)-4-{[2-({4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl}amino)-5-fluoro-4-pyrimidinyl]amino}benzamide

Aurora A inhibitor 1

2,4-Bisanilinopyrimidine,10

Aurora A Inhibitor I

N-(2-chlorophenyl)-4-{[2-({4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}benzamide

N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]benzamide

S1451_Selleck

HMS3265K21

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Price: $109/10mM*1mLinDMSO

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