极光A抑制剂I(TC-S 7010)

• 常用名: 极光A抑制剂I(TC-S 7010)
• 英文名: Aurora A Inhibitor I
• CAS号: 1158838-45-9
• 分子量: 588.075
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₃₁H₃₁ClFN₇O₂
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

极光A抑制剂I(TC-S 7010)用途

Aurora A inhibitor I是有效,高度选择的 Aurora A 抑制剂,IC50值为3.4 nM。

极光A抑制剂I(TC-S 7010)名称

• 中文名: N-(2-氯苯基)-4-[[2-[[4-[2-(4-乙基-1-哌嗪基)-2-氧代乙基]苯基]氨基]-5-氟-4-嘧啶基]氨基]苯甲酰胺
• 英文名: N-(2-chlorophenyl)-4-[[2-[4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]anilino]-5-fluoropyrimidin-4-yl]amino]benzamide
• 中文别名: N-(2-氯苯基)-4-(2-(4-(2-(4-乙基哌嗪-1-基)-2-氧代乙基)苯基氨基)-5-氟嘧啶-4-基氨基)苯甲酰胺 | 洋橄榄叶素

极光A抑制剂I(TC-S 7010)生物活性

• 描述: Aurora A inhibitor I是有效,高度选择的 Aurora A 抑制剂,IC50值为3.4 nM。
• 相关类别:
  研究领域 >> 癌症
• 靶点实验:

  Aurora A:3.4 nM (IC50)

  Aurora B:3.4 μM (IC50)

• 体外研究: Aurora A抑制剂I是特别选择性的Aurora A抑制剂。 Aurora A抑制剂I是一种有用的工具化合物,用于研究Aurora A激酶的细胞作用,而没有抑制Aurora B的并发症[1]。
• 参考文献:

  [1]. Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E, Liang J, Moffat J, Phillips G, Pulk R, Rawson TE, Ultsch M, Walker L, Wiesmann C, Zhang B, Zhu BY, Cochran AG.A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.J Med Chem. 2009 May 28;52(10):3300-7.

极光A抑制剂I(TC-S 7010)物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₃₁H₃₁ClFN₇O₂
• 分子量: 588.075
• 精确质量: 587.221191
• PSA: 102.49000
• LogP: 4.39
• 外观性状: white to beige
• 折射率: 1.679
• 储存条件: 2-8°C
• 水溶解性: DMSO: soluble10mg/mL, clear

极光A抑制剂I(TC-S 7010)安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22
• 危险品运输编码: NONH for all modes of transport

极光A抑制剂I(TC-S 7010)靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：In Vitro Kinase Assay from Article 10.1021/cb200305u: "Selective aurora kinase inhibi... 来源：BindingDB 靶标：N/A External Id：BindingDB_5482_1

实验名称：Confirmatory qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinas... 来源：NCGC External Id：IP6K1-f1-cherrypicks

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

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极光A抑制剂I(TC-S 7010)英文别名

• Aurora-A Inhibitor I
• N-(2-Chlorophenyl)-4-{[2-({4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl}amino)-5-fluoro-4-pyrimidinyl]amino}benzamide
• Aurora A inhibitor 1
• 2,4-Bisanilinopyrimidine,10
• Aurora A Inhibitor I
• N-(2-chlorophenyl)-4-{[2-({4-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]amino}benzamide
• N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]benzamide
• S1451_Selleck
• HMS3265K21