Cys-McMMAF
Modify Date: 2025-08-26 16:24:49
Cys-McMMAF structure
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Common Name | Cys-McMMAF | ||
|---|---|---|---|---|
| CAS Number | 1160590-05-5 | Molecular Weight | 1046.32 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C52H83N7O13S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Cys-McMMAFCys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models)[1]. |
| Name | Cys-McMMAF |
|---|
| Description | Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models)[1]. |
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| Related Catalog | |
| In Vivo | Cys-McMMAF (0.3 mg/kg, 3 mg/kg; 静脉注射; 单剂量) 在食蟹猴体内的稳定性一般，衰退时间短[1]。 在裸鼠 (nu/nu) 中的药代动力学分析[1] Model/IV Dose (mg/kg) Cmax (ng/mL) Tmax (hr) AUC0-336 (ng·h/mL) t1/2 (day) Non-Tumor 1 0.192 8 14.6 2.1 Tumor 1 0.146 8 28.2 6.0 Non-Tumor 10 0.951 8 58.5 3.0 Tumor 10 0.945 8 81.9/td> 2.9 |
| References |
| Molecular Formula | C52H83N7O13S |
|---|---|
| Molecular Weight | 1046.32 |