1160590-05-5
1160590-05-5 structure
- Name: Cys-McMMAF
- Chemical Name: Cys-McMMAF
- CAS Number: 1160590-05-5
- Molecular Formula: C52H83N7O13S
- Molecular Weight: 1046.32
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2023-06-02 04:32:42
- Modify Date: 2025-08-26 16:24:49
-
Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models)[1].
| Name | Cys-McMMAF |
|---|
| Description | Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models)[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Cys-McMMAF (0.3 mg/kg, 3 mg/kg; 静脉注射; 单剂量) 在食蟹猴体内的稳定性一般，衰退时间短[1]。 在裸鼠 (nu/nu) 中的药代动力学分析[1] Model/IV Dose (mg/kg) Cmax (ng/mL) Tmax (hr) AUC0-336 (ng·h/mL) t1/2 (day) Non-Tumor 1 0.192 8 14.6 2.1 Tumor 1 0.146 8 28.2 6.0 Non-Tumor 10 0.951 8 58.5 3.0 Tumor 10 0.945 8 81.9/td> 2.9 |
| References |
| Molecular Formula | C52H83N7O13S |
|---|---|
| Molecular Weight | 1046.32 |