(+/-)-4-Hydroxy Mephenytoin structure
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Common Name | (+/-)-4-Hydroxy Mephenytoin | ||
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CAS Number | 61837-65-8 | Molecular Weight | 234.251 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C12H14N2O3 | Melting Point | 153-154ºC | |
MSDS | Chinese USA | Flash Point | 48.2 °F | |
Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger |
Use of (+/-)-4-Hydroxy Mephenytoin4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate. |
Name | (+/-)-4-Hydroxy Mephenytoin |
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Synonym | More Synonyms |
Description | 4-Hydroxymephenytoin is a metabolism of an antiepileptic drug mephenytoin, which is used as a CYP2C19 substrate. |
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Related Catalog | |
In Vitro | 4-Hydroxymephenytoin is a metabolism of mephenytoin, which is an antiepileptic drug, and used as a CYP2C19 substrate[1]. 4-Hydroxymephenytoin (4'-Hydroxymephenytoin) is used for developing UltraPerformance LC (UPLC) tandem mass spectrometry assays for evaluating CYP probe drugs and their relevant metabolites in human urine or plasma samples[2]. |
References |
Density | 1.3±0.1 g/cm3 |
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Melting Point | 153-154ºC |
Molecular Formula | C12H14N2O3 |
Molecular Weight | 234.251 |
Exact Mass | 234.100449 |
PSA | 69.64000 |
LogP | 0.66 |
Index of Refraction | 1.568 |
Storage condition | 2-8℃ |
Symbol |
GHS02, GHS06, GHS08 |
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Signal Word | Danger |
Hazard Statements | H225-H301 + H311 + H331-H370 |
Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
RIDADR | UN1230 - class 3 - PG 2 - Methanol |
Flash Point(F) | 48.2 °F |
Flash Point(C) | 9 °C |
The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet.
Biochem. Pharmacol. 93(3) , 389-400, (2015) There is an unmet medical need for novel NAFLD treatments. Here we have examined the effects of liver-selective NO donor (V-PYRRO/NO) as compared with metformin on hepatic steatosis and glucose tolera... |
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Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations.
Nanoscale Res. Lett. 9(1) , 642, (2014) Nano-sized particles are known to interfere with drug-metabolizing cytochrome P450 (CYP) enzymes, which can be anticipated to be a potential source of unintended adverse reactions, but the mechanisms ... |
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Quantification of mephenytoin and its metabolites 4'-hydroxymephenytoin and nirvanol in human urine using a simple sample processing method.
Rapid Commun. Mass Spectrom. 18(15) , 1675-80, (2004) A reliable and easy to use liquid chromatography/tandem mass spectrometry (LC/MS/MS) method without the use of sample extraction was developed for the simultaneous quantification of urinary concentrat... |
4-hydroxy mephenytoin |
5-Ethyl-5-(4-hydroxyphenyl)-3-methyl-2,4-imidazolidinedione |
5-Ethyl-5-(4-hydroxyphenyl)-3-methylimidazolidine-2,4-dione |
2,4-Imidazolidinedione, 5-ethyl-5-(4-hydroxyphenyl)-3-methyl- |
4-Hydroxymephenytoin |