Desmethyl-YM 298198

• 常用名: Desmethyl-YM 298198
• 英文名: Desmethyl-YM 298198
• CAS号: 1177767-57-5
• 分子量: 364.89
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₁ClN₄OS
• 熔点: N/A
• 闪点: N/A

Desmethyl-YM 298198用途

Desmethyl-YM-298198 Hydrochloride 是一种高亲和力、选择性、非竞争性 mGluR1 拮抗剂 (IC50: 16 nM)。Desmethyl-YM-298198 Hydrochloride 对 Streptozotocin (HY-13753) 诱导的痛觉过敏小鼠具有镇痛作用。

Desmethyl-YM 298198名称

• 英文名: Desmethyl-YM 298198

Desmethyl-YM 298198生物活性

• 描述: Desmethyl-YM-298198 Hydrochloride 是一种高亲和力、选择性、非竞争性 mGluR1 拮抗剂 (IC50: 16 nM)。Desmethyl-YM-298198 Hydrochloride 对 Streptozotocin (HY-13753) 诱导的痛觉过敏小鼠具有镇痛作用。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 靶点:

  16 nM (mGluR1)[1]

• 参考文献:

  [1]. Kohara A, et al. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1. J Pharmacol Exp Ther. 2005 Oct;315(1):163-9.

Desmethyl-YM 298198物理化学性质

• 分子式: C₁₇H₂₁ClN₄OS
• 分子量: 364.89
• 精确质量: 364.112457

Desmethyl-YM 298198英文别名

• MFCD08458897
• 6-Amino-N-cyclohexyl-3-methyl[1,3]thiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride (1:1)
• Thiazolo[3,2-a]benzimidazole-2-carboxamide, 6-amino-N-cyclohexyl-3-methyl-, hydrochloride (1:1)