22-(4′-py)-JA
Modify Date: 2024-01-03 11:47:46
22-(4′-py)-JA structure
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Common Name | 22-(4′-py)-JA | ||
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| CAS Number | 1178895-15-2 | Molecular Weight | 598.60 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H30N4O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 22-(4′-py)-JA22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC)[1]. |
| Name | 22-(4′-py)-JA |
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| Description | 22-(4′-py)-JA is a semisynthetic derivative of junamycin A (JA) that can be isolated from the Thai blue sponge (Xestospongia sp.). 22-(4′-py)-JA has antimetastatic activity and can inhibit AKT/mTOR/p70S6K signaling. 22-(4′-py)-JA inhibits tumor cell invasion and tube formation in human umbilical vein endothelial cells (HUVEC), downregulates metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF). 22-(4′-py)-JA has potent anticancer activity against non-small cell lung cancer (NSCLC)[1]. |
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| Related Catalog | |
| In Vivo | 22-(4′-py)-JA |
| References |
| Molecular Formula | C32H30N4O8 |
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| Molecular Weight | 598.60 |