AF-DX 384

Modify Date: 2024-01-04 09:31:32

AF-DX 384 Structure
AF-DX 384 structure
Common Name AF-DX 384
CAS Number 118290-26-9 Molecular Weight 478.630
Density 1.1±0.1 g/cm3 Boiling Point 618.4±55.0 °C at 760 mmHg
Molecular Formula C27H38N6O2 Melting Point N/A
MSDS N/A Flash Point 327.8±31.5 °C

 Use of AF-DX 384


AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively)[1]. AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine[2].

 Names

Name AFDX384
Synonym More Synonyms

 AF-DX 384 Biological Activity

Description AF-DX 384 is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively)[1]. AF-DX 384 reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine[2].
Related Catalog
References

[1]. Dörje F, et al. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther. 1991 Feb;256(2):727-33.

[2]. Vannucchi MG, et al. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats. Neuroscience. 1997 Aug;79(3):837-46.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 618.4±55.0 °C at 760 mmHg
Molecular Formula C27H38N6O2
Molecular Weight 478.630
Flash Point 327.8±31.5 °C
Exact Mass 478.305634
LogP 3.48
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.570

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

MFCD00884624
N-(2-{2-[(Dipropylamino)methyl]-1-piperidinyl}ethyl)-6-oxo-5,6-dihydro-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
N-(2-{2-[(Dipropylamino)methyl]piperidin-1-yl}ethyl)-6-oxo-5,6-dihydro-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-
AFDX384
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