Ferric ammonium citrate

Modify Date: 2024-01-02 18:04:41

Ferric ammonium citrate Structure
Ferric ammonium citrate structure
 Common Name Ferric ammonium citrate
CAS Number 1185-57-5 Molecular Weight 261.975
Density 1.8 g/cm3 (20ºC) Boiling Point 197ºC
Molecular Formula C6H8FeNO7 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Ferric ammonium citrate


Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis[1]. Ammonium iron(III) citrate can enhance protein production[2].

 Names

Name Ammonium ferric citrate
Synonym More Synonyms

 Ferric ammonium citrate Biological Activity

Description Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis[1]. Ammonium iron(III) citrate can enhance protein production[2].
Related Catalog
In Vitro Ammonium iron(III) citrate (Ammonium ferric citrate; 1, 5, 10, 15 mM; 24 hours) with 5 mM induces cell death in HT1080 cells. AML12 cells were highly resistant to Ammonium iron(III) citrate, as they maintained cell viability about 80%. Ammonium iron(III) citrate can be actively transported into cells by specific transporter[1]. Ammonium iron(III) citrate (6, 12, 18 mg/L) has a higher biomas for Chlorella vulgaris FSP-E (CV) in BG-11 medium with 12 mg/L and 18 mg/L[2].
References

[1]. Shenglin Fang, et al. Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303.

[2]. Yu-Cheng Lai, et al. Towards protein production and application by using Chlorella species as circular economy. Bioresour Technol. 2019 Oct;289:121625.

 Chemical & Physical Properties

Density 1.8 g/cm3 (20ºC)
Boiling Point 197ºC
Molecular Formula C6H8FeNO7
Molecular Weight 261.975
Exact Mass 261.965027
PSA 102.37000
Water Solubility 1200 g/L (20 ºC)

 MSDS

Name: Ammonium Iron(III)-Citrate Material Safety Data Sheet
Synonym: Ferric Ammonium Citrate, Citric Acid Ammonium Iron (3+) Salt
CAS: 1185-57-5
Section 1 - Chemical Product MSDS Name:Ammonium Iron(III)-Citrate Material Safety Data Sheet
Synonym:Ferric Ammonium Citrate, Citric Acid Ammonium Iron (3+) Salt
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
1185-57-5 FERRIC AMMONIUM CITRATE 100 214-686-6
Hazard Symbols: None Listed.
Risk Phrases: None Listed.
Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause irritation, pain, blurred vision, and possible burns.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. Inorganic iron compounds may cause gastrointestinal irritation and damage, vomiting, pulmonary edema, convulsions, rapid heart beat and low blood pressure. Ingestion of iron compounds may cause hemorrhage and necrosis of the stomach with shock, severe diarrhea, and possible coma.
Inhalation:
May cause respiratory tract irritation.
Chronic:
No information found.
Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Antidote: The use of Deferoxamine as a chelating agent should be determined only by qualified medical personnel.
Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Do not store in direct sunlight. Keep containers tightly closed.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Appearance: yellow to green
Odor: None reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Decomposes.
Freezing/Melting Point: Decomposes.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Soluble.
Specific Gravity/Density: 1.8 @ 20C
Molecular Formula: Mixture
Molecular Weight: 0
Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents - light.
Hazardous Decomposition Products:
Ammonia.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1185-57-5: GE7540000 LD50/LC50:
Not available.
Carcinogenicity:
FERRIC AMMONIUM CITRATE - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Other No information available.
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.
Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 1185-57-5: No information available.
United Kingdom Occupational Exposure Limits
Canada
CAS# 1185-57-5 is listed on Canada's DSL List.
CAS# 1185-57-5 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 1185-57-5: OEL-DENMARK:TWA 1 mg(Fe)/m3 JANUARY 1993
OEL-FINLAND:TWA 1 mg(Fe)/m3 JANUARY 1993
OEL-THE NETHERLANDS:TWA 1 mg(Fe)/m3 JANUARY 1993
OEL-SWITZERLAND:TWA 1 mg(Fe)/m3 JANUARY 1993
OEL-UNITED KINGDOM:TWA 1 mg(Fe)/m3;STEL 2 mg(Fe)/m3 JANUARY 1993
US FEDERAL
TSCA
CAS# 1185-57-5 is listed on the TSCA inventory.

SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GE7540000
CHEMICAL NAME :
Citric acid, ammonium iron(3+) salt
CAS REGISTRY NUMBER :
1185-57-5
LAST UPDATED :
199712
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C6-H8-O7.xFe.xH4-N

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR UN 9118
WGK Germany 3
RTECS GE7540000
HS Code 2918150000

 Customs

HS Code 2918150000
Summary 2918150000. other salts and esters of citric acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:4ABXY(export license,certificate of inspection for goods inward,certificate of inspection for goods outwardexport license(processing trade),export license(border small volume trade)). MFN tariff:6.5%. General tariff:30.0%

 Articles30

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 Synonyms

Ferric
EINECS 214-686-6
Iron(3+) 2-hydroxy-1,2,3-propanetricarboxylate ammoniate (1:1:1)
Ferricammoniumcitrae
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, ammonium iron(3+) salt (1:1:1)
MFCD00013099
Ammonium iron(III) citrate
Ammonium Ferric Citrate
Ammoniumironcitrate
IRON AMMONIUM CITRATE
Citric acid iron ammonium
Amonium Iron(III) Citrate Supplement
Ironandammoniumcit-rate
AmmoniumFerricCitrateUsp
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