Trimipramine-d3 maleate

Modify Date: 2024-01-29 20:40:40

Trimipramine-d3 maleate structure	Common Name	Trimipramine-d3 maleate
	CAS Number	1185245-93-5	Molecular Weight	410.506
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₀N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	9℃
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Use of Trimipramine-d3 maleate

Trimipramine-d3 maleate is the deuterium labeled Trimipramine maleate. Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively[1][2].

Name	UNII:269K6498LD
Synonym	More Synonyms

Description	Trimipramine-d3 maleate is the deuterium labeled Trimipramine maleate. Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Jenck F, et al. Evidence for a role of 5-HT1C receptors in the antiserotonergic properties of some antidepressant drugs. Eur J Pharmacol. 1993 Feb 9;231(2):223-9. [3]. Juorio AV, et al. The effects of chronic trimipramine treatment on biogenic amine metabolism and on dopamine D2, 5-HT2 and tryptamine binding sites in rat brain. Gen Pharmacol. 1990;21(5):759-62.

Molecular Formula	C₂₄H₃₀N₂O₄
Molecular Weight	410.506
Flash Point	9℃
Exact Mass	410.220551
Storage condition	2-8°C

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	7-16-36/37-45
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution

5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N,β-trimethyl-, (2Z)-2-butenedioate (1:1)

UNII:269K6498LD

UNII:D28E1043W5

3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine (2Z)-but-2-enedioate (1:1)

3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethyl-1-propanamine (2Z)-2-butenedioate (1:1)

UNII:I412286V22

Trimipramine-d3 maleate

Use of Trimipramine-d3 maleate

Names

Trimipramine-d3 maleate Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms