ALW-II-41-27

Modify Date: 2024-01-09 13:40:05

Use of ALW-II-41-27

ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC50 of 11 nM for Eph2.

Name	N-[5-[[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]carbamoyl]-2-methylphenyl]-5-thiophen-2-ylpyridine-3-carboxamide
Synonym	More Synonyms

Description	ALW-II-41-27 is a Eph family tyrosine kinase inhibitor with an IC50 of 11 nM for Eph2.
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Ephrin Receptor Research Areas >> Cancer
Target	IC50: 11 nM (Eph2)[1]
In Vitro	ALW-II-41-27 inhibits Ba/F3 cells transformed with Tel fusions of EphA3, Kit, Fms, KDR, FLT1, FGR, Src, Lyn, Bmx, and Bcr-Abl with an EC50 below 500 nM. ALW-II-41-27 exhibits cross reactivity with Bcr-Abl. ALW-II-41-27 inhibits b-raf, CSF1R, DDR1, DDR2, EphA2, EphA5, EphA8, EphB1, EphB2, EphB3, Frk, Kit, Lck, p38α, p38β, PDGFRα, PDGFRβ, and Raf1 and many more demonstrating how introduction of the thiophene group can have a tremendous impact on kinase selectivity[1].
References	[1]. Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters (2009), 19(15), 4467-4470. [2]. Song W, et al. Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancers. Oncogene. 2017 Jun 5.

3-amino-N-[4-[(...

CAS#:872332-67-7

5-(2-thienyl)ni...

CAS#:306934-96-3

~47%

ALW-II-41-27

CAS#:1186206-79-0

Precursor 2
CAS#:872332-67-7 3-amino-N-[4-[(... CAS#:306934-96-3 5-(2-thienyl)ni...
DownStream 0

hms2043h01

hms2218g07

cs-1203

alw-ii-41-27

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