Probenecid-d14

Modify Date: 2024-08-19 23:19:00

Probenecid-d14 Structure
Probenecid-d14 structure
Common Name Probenecid-d14
CAS Number 1189657-87-1 Molecular Weight 299.445
Density 1.2±0.1 g/cm3 Boiling Point 438.0±47.0 °C at 760 mmHg
Molecular Formula C13H5D14NO4S Melting Point N/A
MSDS N/A Flash Point 218.7±29.3 °C

 Use of Probenecid-d14


Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].

 Names

Name Probenecid-d14
Synonym More Synonyms

 Probenecid-d14 Biological Activity

Description Probenecid-d14 is the deuterium labeled Probenecid. Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Koch SE, et al. Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation. J Mol Cell Cardiol. 2012 Jul;53(1):134-44.

[3]. Bakos E, et al. Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8.

[4]. Greene TA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6(5):e20123.

[5]. Silverman W, et al. Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol. 2008 Sep;295(3):C761-7.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 438.0±47.0 °C at 760 mmHg
Molecular Formula C13H5D14NO4S
Molecular Weight 299.445
Flash Point 218.7±29.3 °C
Exact Mass 299.191345
LogP 3.30
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.542

 Synonyms

4-{Bis[(2H7)propyl]sulfamoyl}benzoic acid
Benzoic acid, 4-[(dipropyl-d7-amino)sulfonyl]-
PROBENECID-D14