5-Aminosalicylic acid-13C6

Modify Date: 2024-04-05 14:13:18

5-Aminosalicylic acid-13C6 Structure
5-Aminosalicylic acid-13C6 structure
 Common Name 5-Aminosalicylic acid-13C6
CAS Number 1189709-96-3 Molecular Weight 159.09100
Density N/A Boiling Point N/A
Molecular Formula C7H7NO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Aminosalicylic acid-13C6


5-Aminosalicylic acid-13C6 is the 13C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].

 Names

Name 5-amino-2-hydroxybenzoic acid
Synonym More Synonyms

 5-Aminosalicylic acid-13C6 Biological Activity

Description 5-Aminosalicylic acid-13C6 is the 13C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60.  

[3]. Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 2813(20):2872-7.  

[4]. Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov34(11):2580-6.  

 Chemical & Physical Properties

Molecular Formula C7H7NO3
Molecular Weight 159.09100
Exact Mass 159.06300
PSA 83.55000
LogP 1.25380

 Synonyms

Mesalazine-13C6
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Chemsrc provides 5-Aminosalicylic acid-13C6(CAS#:1189709-96-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 5-Aminosalicylic acid-13C6 are included as well.>> amp version: 5-Aminosalicylic acid-13C6

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