Peptide YY (human) trifluoroacetate salt

Modify Date: 2024-01-02 09:26:58

Peptide YY (human) trifluoroacetate salt structure	Common Name	Peptide YY (human) trifluoroacetate salt
	CAS Number	118997-30-1	Molecular Weight	4309.81
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉₄H₂₉₅N₅₅O₅₇	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Peptide YY (human) trifluoroacetate salt

Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.

Name	Peptide YY human
Synonym	More Synonyms

Description	Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the Neuropeptide Y receptors.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor Peptides Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	Neuropeptide Y receptor[1]
In Vitro	The gut hormone peptide YY ( PYY) belongs to the pancreatic polypeptide (PP) family along with PP and neuropeptide Y (NPY). These peptides mediate their effects through the NPY receptors of which there are several subtypes (Y1, Y2, Y4, and Y5)[1]. Pancreatic polypeptide YY (Peptide YY), a small peptide consisting of 36 amino acids, is originally isolated from porcine intestine and is secreted from the neuroendocrine cells (L cells) in the mucosa of the gastrointestinal tract, but it has been localized to other locations associated with the digestive system[2].
In Vivo	Peptide YY is capable of strongly inhibiting secretin-stimulated pancreatic secretion. A very low dose of Peptide YY (10-20 pmol/kg) significantly decreases the pancreatic secretion of bicarbonate as well as fluid that is stimulated by a single dose of secretin (0.1 unit/kg). A dose of Peptide YY of 100-200 pmol/kg causes a 70-80% reduction of the pancreatic bicarbonate and fluid secretion[3]. Peptide YY is localised to blood vessels and atherosclerotic plaques of rabbits. It causes vasoconstriction of the vascular tree[2].
Animal Admin	Cats[3] The inhibitory effects of Peptide YY on pancreatic exocrine secretion are studied by using an anesthetized adult (4 kg) cat. Infusion of secretin and CCK (1.5 units/ kg/hr each) in saline solution is made through the saphenous vein by using a perfusion pump at a flow rate of 10 ml/hr. Infusion or single injection of Peptide YY (10-250 pmol/kg) is also made through the saphenous vein. Pancreatic juice from the cannulated pancreatic duct is collected in test tubes for 10-min periods by using a fraction collector. The volume of the juice and A280 are measured. Bicarbonate is determined by the titration method[3]. Rabbits[2] New Zealand White rabbits are fed an atherogenic diet and control animals fed a normal diet for 4 weeks. Immunohistochemistry is used to determine the localization of Peptide YY and eNOS in the aorta. The aorta, carotid, renal, iliac, inferior mesenteric, and renal interlobular arteries are removed, mounted in organ baths, and subjected to doses of Peptide YY (1-100 nM) and then acetylcholine (1 μM)[2].
References	[1]. Peptide YY, et al. The gut hormone peptide YY regulates appetite. Ann N Y Acad Sci. 2003 Jun;994:162-8. [2]. Tatemoto K, et al. Isolation and characterization of peptide YY (PYY ), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci U S A. 1982 Apr;79(8):2514-8. [3]. Smith RM, et al. Role of Peptide YY in blood vessel function and atherosclerosis in a rabbit model. Clin Exp Pharmacol Physiol. 2015 Jun;42(6):648-52.

Molecular Formula	C₁₉₄H₂₉₅N₅₅O₅₇
Molecular Weight	4309.81
Storage condition	−20°C

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RIDADR	NONH for all modes of transport
WGK Germany	3

Human peptide YY

MFCD00081843

Peptide YY (PYY), human

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Product Name: Peptide YY (human) trifluoroacetate salt
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China
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China
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