Leflunomide-d4
Modify Date: 2024-01-31 17:34:23
Leflunomide-d4 structure
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Common Name | Leflunomide-d4 | ||
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| CAS Number | 1189987-23-2 | Molecular Weight | 274.232 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 289.3±40.0 °C at 760 mmHg | |
| Molecular Formula | C12H5D4F3N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 128.8±27.3 °C | |
Use of Leflunomide-d4Leflunomide-d4 (HWA486-d4) is the deuterium labeled Leflunomide. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic drug[1][2]. |
| Name | 5-Methyl-N-[4-(trifluoromethyl)(2H4)phenyl]-1,2-oxazole-4-carboxamide |
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| Synonym | More Synonyms |
| Description | Leflunomide-d4 (HWA486-d4) is the deuterium labeled Leflunomide. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic drug[1][2]. |
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| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 289.3±40.0 °C at 760 mmHg |
| Molecular Formula | C12H5D4F3N2O2 |
| Molecular Weight | 274.232 |
| Flash Point | 128.8±27.3 °C |
| Exact Mass | 274.086731 |
| LogP | 1.95 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.541 |
| Hazard Codes | Xi |
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| 4-Isoxazolecarboxamide, 5-methyl-N-[4-(trifluoromethyl)phenyl-2,3,5,6-d]- |
| 5-Methyl-N-[4-(trifluoromethyl)(H)phenyl]-1,2-oxazole-4-carboxamide |