LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2

Modify Date: 2024-01-11 19:26:09

LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2 structure	Common Name	LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2
	CAS Number	119386-39-9	Molecular Weight	987.16100
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₀H₇₈N₁₈O₁₁	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2

Myosin light chain kinase fragment 11-19 amide (MLCK(11-19) amide) is a substrate-specific peptide inhibitor of MLCK. Myosin light chain kinase fragment 11-19 amide inhibits hypotonicity-induced Ca2+ entry. Myosin light chain kinase fragment 11-19 amide can be used in the research of human cervical cancer[1][2].

Name	h-lys-lys-arg-ala-ala-arg-ala-thr-ser-nh2
Synonym	More Synonyms

Description	Myosin light chain kinase fragment 11-19 amide (MLCK(11-19) amide) is a substrate-specific peptide inhibitor of MLCK. Myosin light chain kinase fragment 11-19 amide inhibits hypotonicity-induced Ca2+ entry. Myosin light chain kinase fragment 11-19 amide can be used in the research of human cervical cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	MLCK[1]
In Vitro	Myosin light chain kinase fragment 11-19 amide (5 μM) reduces the amplitude and rate of activation of noradrenaline-evoked non-selective cation current (Icat) in rabbit portal vein myocytes[1]. Myosin light chain kinase fragment 11-19 amide inhibits swelling-activated taurine transport with an IC50 value of 2.0 µM[2]. Myosin light chain kinase fragment 11-19 amide (10 µM) inhibits β2-integrin-mediated adhesion in neutrophils treated with KT5720 (25 µM)[3].

Molecular Formula	C₄₀H₇₈N₁₈O₁₁
Molecular Weight	987.16100
Exact Mass	986.61000
PSA	518.21000
LogP	0.20500

LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2 MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Minimum requirements for inhibition of smooth-muscle myosin light-chain kinase by synthetic peptides.

Biochem. J. 257 , 73, (1989)

Although the amino acid residues that are important for peptide substrates of myosin light-chain kinase have been reported, those that are important for peptide inhibitors of this enzyme have not prev...

Smooth muscle myosin kinase requires residues on the COOH-terminal side of the phosphorylation site. Peptide inhibitors.

J. Biol. Chem. 261 , 25, (1986)

The COOH-terminal residue in peptide analogs of the phosphorylation site sequence in smooth muscle myosin light chains, Lys11-Lys12-Arg13-Ala-Ala-Arg16-Ala-Thr-Ser19 -(P)Asn20-Val21-Phe22-Ala23, were ...

Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain.

J. Biol. Chem. 262 , 11958-11963, (1987)

A synthetic peptide modeled after the calmodulin (CaM)-binding domain of rabbit skeletal muscle myosin light chain kinase, Lys-Arg-Arg-Trp-Lys5-Lys-Asn-Phe-Ile-Ala10-Val-Ser-Ala-Ala-+ ++Asn15-Arg-Phe-...

MYOSIN KINASE INHIBITING PEPTIDE

Myosin Light Chain Kinase Fragment 11-19 amide

LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-AMIDE

LYS-LYS-ARG-ALA-ALA-ARG-ALA-THR-SER-NH2

KKRAARATS-NH2

myosin light chain kinase fragment 11-19 amide

MYOSIN LIGHT CHAIN KINASE (11-19) AMIDE