Dabigatran-13C6

Modify Date: 2024-04-06 13:24:08

Dabigatran-13C6 structure	Common Name	Dabigatran-13C6
	CAS Number	1210608-88-0	Molecular Weight	477.46700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₅N₇O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Dabigatran-13C6

Dabigatran-13C6 is the 13C labeled Dabigatran[1]. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[2][3].

Name	3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid
Synonym	More Synonyms

Description	Dabigatran-13C6 is the 13C labeled Dabigatran[1]. Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[2][3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Wienen W, Stassen JM, Priepke H, In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62. [3]. Hauel NH, et al. Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem. 2002 Apr 25;45(9):1757-66. [4]. Wienen W, et al. Effects of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate, on thrombus formation and bleeding time in rats. Thromb Haemost. 2007 Aug;98(2):333-8.

Molecular Formula	C₂₅H₂₅N₇O₃
Molecular Weight	477.46700
Exact Mass	477.22200
PSA	150.22000
LogP	3.85900

bibr 953zw

Dabigatran-13C6

Use of Dabigatran-13C6

Names

Dabigatran-13C6 Biological Activity

Chemical & Physical Properties

Synonyms