AN-3485

Modify Date: 2024-01-02 09:26:13

AN-3485 Structure
AN-3485 structure
Common Name AN-3485
CAS Number 1213827-99-6 Molecular Weight 289.52
Density N/A Boiling Point N/A
Molecular Formula C14H13BClNO3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AN-3485


AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.

 Names

Name AN-3485

 AN-3485 Biological Activity

Description AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.
Related Catalog
Target

IC50:AN-3485 inhibits TLR2-, TLR3-, TLR4-, and TLR5-mediates TNF-a, IL-1b, and IL-6 release with IC50 values of human PBMCs (103±68 nM, 68±63 nM, 72±33 nM)and isolated monocytes (77±26 nM; 18±6.7 nM; 32±6.5 nM) [1] .

References

[1]. Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344(2):436-46.

 Chemical & Physical Properties

Molecular Formula C14H13BClNO3
Molecular Weight 289.52
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