4-oxo-27-TBDMS Withaferin A
Modify Date: 2024-01-12 16:57:49
4-oxo-27-TBDMS Withaferin A structure
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Common Name | 4-oxo-27-TBDMS Withaferin A | ||
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| CAS Number | 1214886-31-3 | Molecular Weight | 582.843 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 651.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C34H50O6Si | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 288.8±27.0 °C | |
Use of 4-oxo-27-TBDMS Withaferin A27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent[1]. |
| Name | 4-oxo-27-TBDMS Withaferin A |
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| Synonym | More Synonyms |
| Description | 27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent[1]. |
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| Related Catalog | |
| In Vitro | 27-TBDMS-4-Dehydrowithaferin A (compound 9b; 48 h) exhibits potent antiproliferative effects on HeLa (IC50=1.7 μM), A-549 (IC50=5.3 μM), MCF-7 (IC50=0.5 μM), and normal Vero cells (IC50=3.1 μM)[1]. 27-TBDMS-4-Dehydrowithaferin A (24 μM; 48 h) activates caspase-3 in HeLa cells[1]. 27-TBDMS-4-Dehydrowithaferin A (8 μM; 1-4 h) with a longer incubation period (2-4 h) leads to apoptosis, effect that was maintained at concentrations of 12 and 16 μM[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 651.3±55.0 °C at 760 mmHg |
| Molecular Formula | C34H50O6Si |
| Molecular Weight | 582.843 |
| Flash Point | 288.8±27.0 °C |
| Exact Mass | 582.337646 |
| LogP | 6.88 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.547 |
| Ergosta-2,24-diene-1,4,26-trione, 27-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6:22,26-diepoxy-, (5β,6β,22R)- |
| 4-oxo-27-TBDMS Withaferin A |
| (5β,6β,22R)-27-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-5,6:22,26-diepoxyergosta-2,24-diene-1,4,26-trione |