NBI 27914 hydrochloride
Modify Date: 2024-01-12 20:15:01
NBI 27914 hydrochloride structure
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Common Name | NBI 27914 hydrochloride | ||
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| CAS Number | 1215766-76-9 | Molecular Weight | 470.651 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H21Cl5N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NBI 27914 hydrochlorideNBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM[1][3][4]. |
| Name | 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM[1][3][4]. |
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| Related Catalog | |
| Target |
Ki: 1.7 nM (CRF1 receptor)[4] |
| In Vivo | NBI 27914 (3~30 mg/kg; i.p.) hydrochloride attenuates the referred abdominal pain at the highest dose tested, it is efficacious both 4 and 24 h post-indomethacin dosing[1]. NBI 27914 (1~10 mg/kg; i.p.) hydrochloride dose dependently attenuates Freund's Complete Adjuvant-induced mechanical hyperalgesia. NBI 27914 (10 mg/kg) hydrochloride reverses the thermal hyperalgesia. NBI 27914 hydrochloride attenuates spinal nerve ligation-induced mechanical hyperalgesia and tactile allodynia with minimal effective doses equal to 5 and 10 mg/kg, respectively[1]. The higher doses of NBI 27914 hydrochloride blocks the behavioral seizures and prevents epileptic discharges in concurrent electroencephalograms recorded from the amygdala[2]. Animal Model: Male CD-1 mice (20~25 g)[1] Dosage: 3~30 mg/kg Administration: I.p. Result: Attenuated the referred abdominal pain at the highest dose tested, it was efficacious both 4 and 24 h post-indomethacin dosing. |
| References |
| Molecular Formula | C18H21Cl5N4 |
|---|---|
| Molecular Weight | 470.651 |
| Exact Mass | 468.020874 |
| 4,6-Pyrimidinediamine, 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)-, hydrochloride (1:1) |
| 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride (1:1) |
| MFCD05662281 |
| 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine hydrochloride (1:1) |