NBI-27914 hydrochloride

更新时间：2025-08-27 13:50:02

NBI-27914 hydrochloride结构式	常用名	NBI-27914 hydrochloride	英文名	NBI 27914 hydrochloride
	CAS号	1215766-76-9	分子量	470.651
	密度	N/A	沸点	N/A
	分子式	C₁₈H₂₁Cl₅N₄	熔点	N/A
	MSDS	N/A	闪点	N/A

NBI-27914 hydrochloride用途

NBI-27914(盐酸盐)是一种选择性促肾上腺皮质激素释放因子1(CRF1)受体拮抗剂,Ki值为1.7 nM[1][3][4]。

英文名	5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride (1:1)
英文别名	更多

描述	NBI-27914(盐酸盐)是一种选择性促肾上腺皮质激素释放因子1(CRF1)受体拮抗剂,Ki值为1.7 nM[1][3][4]。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> CRFR 研究领域 >> 神经疾病
靶点实验	Ki: 1.7 nM (CRF1 receptor)[4]
体内研究	NBI 27914(3~30 mg/kg；i.p.)盐酸盐可在最高试验剂量下减轻所述腹痛,在吲哚美辛给药后4小时和24小时均有效[1]。NBI 27914(1~10 mg/kg；i.p.)盐酸盐剂量依赖性地减轻弗氏完全佐剂诱导的机械性痛觉过敏。NBI 27914(10 mg/kg)盐酸盐逆转热痛觉过敏。NBI 27914盐酸盐分别以5和10 mg/kg的最小有效剂量减弱脊神经结扎引起的机械性痛觉过敏和触觉性痛觉超敏[1]。较高剂量的NBI 27914盐酸盐可阻断行为性癫痫发作,并防止杏仁核记录的并发脑电图中的癫痫放电[2]。动物模型：雄性CD-1小鼠(20~25g)[1]剂量：3~30mg/kg给药：I.p.结果：在最高试验剂量下,消炎痛给药后4和24h均有效。
参考文献	[1]. Peng YL, et al. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010;31(12):2259-2263. [2]. Hummel M, et al. Pain is a salient "stressor" that is mediated by corticotropin-releasing factor-1 receptors. Neuropharmacology. 2010;59(3):160-166. [3]. Baram TZ, et al. The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 1997;770(1-2):89-95. [4]. Chen C, et al. Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. J Med Chem.

分子式	C₁₈H₂₁Cl₅N₄
分子量	470.651
精确质量	468.020874
InChIKey	CPMGENCTAWBLNW-UHFFFAOYSA-N
SMILES	CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl.Cl

实验名称：Cell-based high throughput primary assay to identify activators of GPR151
来源：The Scripps Research Institute Molecular Screening Center
靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of...
来源：The Scripps Research Institute Molecular Screening Center
靶标：N/A
External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of...
来源：The Scripps Research Institute Molecular Screening Center
External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
来源：23265
External Id：IucA Pilot Assay Tocris Library

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4,6-Pyrimidinediamine, 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)-, hydrochloride (1:1)

5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride (1:1)

MFCD05662281

5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine hydrochloride (1:1)