Sarafotoxin C trifluoroacetate salt

Modify Date: 2024-01-02 14:19:33

Sarafotoxin C trifluoroacetate salt structure	Common Name	Sarafotoxin C trifluoroacetate salt
	CAS Number	121695-87-2	Molecular Weight	2515.75000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀₃H₁₄₇N₂₇O₃₇S₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Sarafotoxin C trifluoroacetate salt

Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].

Name	Sarafotoxin S6c
Synonym	More Synonyms

Description	Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Target	Endothelin-B receptor[1]
In Vivo	Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1]. Animal Model: Male Wister rats, exposed to 10% O2 [chronic hypoxic (CH) rats] or room air (control rats) for 2 weeks[1] Dosage: 1 pM-1 mM Administration: Result: Chronic hypoxia had effect on the sensitivity of the main pulmonary arteries to SCS6c, and small vasoconstrictor responses to were evident. Caused vasoconstriction with a maximum response 30% of that to ET-1 in both endothelium-intact and endothelium-denuded vessels.

Molecular Formula	C₁₀₃H₁₄₇N₂₇O₃₇S₅
Molecular Weight	2515.75000
Exact Mass	2513.91000
PSA	1172.52000

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Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes.

Biochem. Biophys. Res. Commun. 175 , 556-561, (1991)

In contrast to endothelin-1 (ET-1) and several of its analogues, sarafotoxin S6c (S6c) was a much more potent inhibitor of [125I]-ET-1 binding in rat hippocampus and cerebellum (Ki approximately 20 pM...

Mechanisms of endothelin-induced venoconstriction in isolated guinea pig mesentery.

J. Pharmacol. Exp. Ther. 289 , 762-767, (1999)

In the present study, endothelin (ET) agonists and receptor selective antagonists were used to characterize ET receptors mediating constriction in guinea pig mesenteric veins (250-300 micrometers diam...

Influence of endothelins and sarafotoxin 6c and L-NAME on renal vasoconstriction in the anaesthetized rat.

Br. J. Pharmacol. 128 , 809-815, (1999)

1. An investigation was performed in pentobarbitone anaesthetized rats to compare the renal vasoconstrictor actions of endothelin-1 (ET-1), endothelin-3 (ET-3) and sarafotoxin 6c and their dependency ...

MFCD00133969

SRTX-c

Sarafotoxin S 6c

Sarafotoxin 6c