Lovastatin-d3 hydroxy acid sodium

Modify Date: 2025-08-25 12:36:48

Lovastatin-d3 hydroxy acid sodium Structure
Lovastatin-d3 hydroxy acid sodium structure
Common Name Lovastatin-d3 hydroxy acid sodium
CAS Number 1217528-38-5 Molecular Weight 447.56
Density N/A Boiling Point N/A
Molecular Formula C24H35D3NaO6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lovastatin-d3 hydroxy acid sodium


Lovastatin-d3 hydroxy acid (Mevinolinic acid-d3) sodium is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].

 Names

Name Lovastatin-d3 hydroxy acid sodium

 Lovastatin-d3 hydroxy acid sodium Biological Activity

Description Lovastatin-d3 hydroxy acid (Mevinolinic acid-d3) sodium is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. A W Alberts, eta al. Mevinolin: A Highly Potent Competitive Inhibitor of Hydroxymethylglutaryl-Coenzyme A Reductase and a Cholesterol-Lowering Agent. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.

 Chemical & Physical Properties

Molecular Formula C24H35D3NaO6
Molecular Weight 447.56
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