ML324
Modify Date: 2024-01-02 16:38:12
ML324 structure
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Common Name | ML324 | ||
|---|---|---|---|---|
| CAS Number | 1222800-79-4 | Molecular Weight | 349.426 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 590.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H23N3O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 310.7±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of ML324ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.IC50 value: 920 nM(JMJD2E) [1]Target: JMJD2 demethylase inhibitorML324 is a probe molecule that displays submicromolar inhibitory activity toward JMJD2E (in vitro) and possesses excellent in vitro ADME properties. In contrast to previously reported inhibitors of the JMJD proteins, ML324 displays excellent cell permeability providing an opportunity for more extensive cell-based studies of JMJD2 enzymes to be undertaken. In addition, ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice. |
| Name | N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.IC50 value: 920 nM(JMJD2E) [1]Target: JMJD2 demethylase inhibitorML324 is a probe molecule that displays submicromolar inhibitory activity toward JMJD2E (in vitro) and possesses excellent in vitro ADME properties. In contrast to previously reported inhibitors of the JMJD proteins, ML324 displays excellent cell permeability providing an opportunity for more extensive cell-based studies of JMJD2 enzymes to be undertaken. In addition, ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 590.1±50.0 °C at 760 mmHg |
| Molecular Formula | C21H23N3O2 |
| Molecular Weight | 349.426 |
| Flash Point | 310.7±30.1 °C |
| Exact Mass | 349.179016 |
| LogP | 2.22 |
| Appearance of Characters | white to light brown |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.629 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble10mg/mL, clear |
| N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide |
| Benzamide, N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)- |
| ML324 |
| ML-324 |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: ML324
- Price: ￥4386.0/100mg ￥766.0/10mg ￥1376.0/25mg ￥2486.0/50mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: ML-324
- Price: $350.0/100mg $650.0/250mg $1300.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
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Price: $103/10mM*1mLinDMSO
Reference only. check more ML324 price