MeIQx-d3
MeIQx-d3 structure
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Common Name | MeIQx-d3 | ||
|---|---|---|---|---|
| CAS Number | 122457-31-2 | Molecular Weight | 216.26 | |
| Density | 1.5g/cm3 | Boiling Point | 458.4ºC at 760 mmHg | |
| Molecular Formula | C11H8D3N5 | Melting Point | >264°C (dec.) | |
| MSDS | N/A | Flash Point | 231ºC | |
Use of MeIQx-d3MeIQx-d3 is the deuterium labeled MeIQx (HY-W355129)[1]. MeIQx is a heterocyclic amine (HAs) compound and a dietary aromatic amine, which can bind covalently to hemoglobin. MeIQx is a mutagenic compound that induces liver tumors[2]. |
| Name | 8-methyl-3-(trideuteriomethyl)imidazo[4,5-f]quinoxalin-2-amine |
|---|---|
| Synonym | More Synonyms |
| Description | MeIQx-d3 is the deuterium labeled MeIQx (HY-W355129)[1]. MeIQx is a heterocyclic amine (HAs) compound and a dietary aromatic amine, which can bind covalently to hemoglobin. MeIQx is a mutagenic compound that induces liver tumors[2]. |
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| Related Catalog | |
| In Vitro | 氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。 MeIQx (0.47 mM；0-120 分钟) 与小鼠血红蛋白共价结合，并被小鼠微粒体激活为代谢物[2]。 |
| In Vivo | MeIQx (2.0-200 mg/kg；腹腔注射) 在雄性 Swiss Webster 小鼠中，以剂量依赖性方式与血红蛋白共价结合[2]。 |
| References |
| Density | 1.5g/cm3 |
|---|---|
| Boiling Point | 458.4ºC at 760 mmHg |
| Melting Point | >264°C (dec.) |
| Molecular Formula | C11H8D3N5 |
| Molecular Weight | 216.26 |
| Flash Point | 231ºC |
| Exact Mass | 216.12000 |
| PSA | 69.62000 |
| LogP | 1.98830 |
| Vapour Pressure | 1.38E-08mmHg at 25°C |
| Index of Refraction | 1.776 |
| Storage condition | Refrigerator |
| Hazard Codes | Xn |
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MeIQx-d3 CAS#:122457-31-2 |
| Literature: Tetrahedron, , vol. 45, # 5 p. 1293 - 1298 |
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MeIQx-d3 CAS#:122457-31-2 |
| Literature: Tetrahedron, , vol. 45, # 5 p. 1293 - 1298 |
|
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MeIQx-d3 CAS#:122457-31-2 |
| Literature: Tetrahedron, , vol. 45, # 5 p. 1293 - 1298 |
|
~%
MeIQx-d3 CAS#:122457-31-2 |
| Literature: Tetrahedron, , vol. 45, # 5 p. 1293 - 1298 |
|
~%
MeIQx-d3 CAS#:122457-31-2 |
| Literature: Tetrahedron, , vol. 45, # 5 p. 1293 - 1298 |
| MeIQx-d3 |