FLLL32

Modify Date: 2024-01-06 21:49:38

FLLL32 Structure
FLLL32 structure
Common Name FLLL32
CAS Number 1226895-15-3 Molecular Weight 464.55
Density N/A Boiling Point N/A
Molecular Formula C28H32O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FLLL32


FLLL32 is a STAT3 inhibitor derived from the natural product curcumin. FLLL32 retains the cellular response to cytokines with anti-tumor activity[1].

 Names

Name flll32
Synonym More Synonyms

 FLLL32 Biological Activity

Description FLLL32 is a STAT3 inhibitor derived from the natural product curcumin. FLLL32 retains the cellular response to cytokines with anti-tumor activity[1].
Related Catalog
Target

STAT3[1]

In Vitro FLLL32 specifically reduces STAT3 phosphorylation at Tyr705 (pSTAT3) and induces apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures[1].
References

[1]. Bill MA, et al. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3inhibition and retains the cellular response to cytokines with anti-tumor activity. Mol Cancer. 2010 Jun 25;9:165.

 Chemical & Physical Properties

Molecular Formula C28H32O6
Molecular Weight 464.55
Exact Mass 464.22000
PSA 71.06000
LogP 5.53630
Storage condition -20℃

 Synonyms

MFCD22200575
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