XE 991 dihydrochloride
Modify Date: 2024-01-05 23:17:16
XE 991 dihydrochloride structure
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Common Name | XE 991 dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 122955-13-9 | Molecular Weight | 449.37 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H22Cl2N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of XE 991 dihydrochlorideXE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively[1]. |
| Name | XE 991 (hydrochloride) |
|---|---|
| Synonym | More Synonyms |
| Description | XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively[1]. |
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| Related Catalog | |
| Target |
IC50: 0.75 µM ( Kv7.1 channel), 0.71 µM (Kv7.2 channel), 0.6 µM (Kv7.2 + Kv7.3 channel), 0.98 μM (M-current)[1] |
| In Vitro | XE 991 dihydrochloride possesses an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action[2]. |
| References |
| Molecular Formula | C26H22Cl2N2O |
|---|---|
| Molecular Weight | 449.37 |
| Exact Mass | 448.110931 |
| PSA | 42.85000 |
| LogP | 6.39650 |
| Storage condition | -20°C |
| 9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-, hydrochloride (1:2) |
| 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride |
| NPE-caged-HPTS |
| 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone dihydrochloride |