XE 991 dihydrochloride
XE 991 dihydrochloride structure
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Common Name | XE 991 dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 122955-42-4 | Molecular Weight | 376.45 | |
| Density | N/A | Boiling Point | 625.3ºC at 760mmHg | |
| Molecular Formula | C26H20N2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 332ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of XE 991 dihydrochlorideXE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively[1]. |
| Name | 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone |
|---|---|
| Synonym | More Synonyms |
| Description | XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively[1]. |
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| Related Catalog | |
| References |
| Boiling Point | 625.3ºC at 760mmHg |
|---|---|
| Molecular Formula | C26H20N2O |
| Molecular Weight | 376.45 |
| Flash Point | 332ºC |
| Exact Mass | 376.15800 |
| PSA | 42.85000 |
| LogP | 4.79250 |
| Vapour Pressure | 6.84E-16mmHg at 25°C |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| RTECS | CB1530000 |
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Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
J. Neurosci. 35 , 11105-17, (2015) Neuron-astrocyte interactions are critical for proper CNS development and function. Astrocytes secrete factors that are pivotal for synaptic development and function, neuronal metabolism, and neuronal... |
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Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus.
PLoS ONE 7 , e30402, (2012) Activation of muscarinic acetylcholine receptors (mAChR) facilitates the induction of synaptic plasticity and enhances cognitive function. In the hippocampus, M(1) mAChR on CA1 pyramidal cells inhibit... |
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Raised activity of L-type calcium channels renders neurons prone to form paroxysmal depolarization shifts.
Neuromolecular Med. 15 , 476-92, (2013) Neuronal L-type voltage-gated calcium channels (LTCCs) are involved in several physiological functions, but increased activity of LTCCs has been linked to pathology. Due to the coupling of LTCC-mediat... |
| 10,10-bis(pyridin-4-ylmethyl)anthracen-9-one,dihydrochloride |