()-trans-C75

Modify Date: 2025-08-25 11:38:26

()-trans-C75 structure	Common Name	()-trans-C75
	CAS Number	1234694-22-4	Molecular Weight	254.32
	Density	1.1±0.1 g/cm3	Boiling Point	432.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₂₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	159.2±22.2 °C

Use of ()-trans-C75

(−)-C75 is a isoform of C75 (HY-12364), which is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM[1][2][3]. C75 is a potent CPT1A activator[5].

Name	(-)-trans-C75
Synonym	More Synonyms

Description	(−)-C75 is a isoform of C75 (HY-12364), which is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM[1][2][3]. C75 is a potent CPT1A activator[5].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)
References	[1]. Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560. [2]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. [3]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7. [4]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33. [5]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Fatty Acid Synthase (FAS)

References

[1]. Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560.

[2]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.

[3]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7.

[4]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.

[5]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

Density	1.1±0.1 g/cm3
Boiling Point	432.1±45.0 °C at 760 mmHg
Molecular Formula	C₁₄H₂₂O₄
Molecular Weight	254.32
Flash Point	159.2±22.2 °C
Exact Mass	254.151810
PSA	63.60000
LogP	3.65
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.489

(2S,3R)-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

(2S,3R)-4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

(2S,3R)-4-Methylene-2-octyl-5-oxotetrahydro-3-furancarboxylic acid

3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-, (2S,3R)-

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

()-trans-C75

Use of ()-trans-C75

Names

()-trans-C75 Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.