(-)-反式-C75

• 常用名: (-)-反式-C75
• 英文名: ()-trans-C75
• CAS号: 1234694-22-4
• 分子量: 254.32
• 密度: 1.1±0.1 g/cm3
• 沸点: 432.1±45.0 °C at 760 mmHg
• 分子式: C₁₄H₂₂O₄
• 熔点: N/A
• 闪点: 159.2±22.2 °C

(-)-反式-C75用途

(−)-C75 是 C75 (HY-12364) 的一种异构体,这是一种合成的脂肪酸合成酶 (FASN) 抑制剂。C75 抑制前列腺癌细胞 PC3 的 IC50 值为 35 μM。C75 是有效的 CPT1A 激活剂。

(-)-反式-C75名称

• 中文名: (-)-反式-C75
• 英文名: (-)-trans-C75

(-)-反式-C75生物活性

• 描述: (−)-C75 是 C75 (HY-12364) 的一种异构体,这是一种合成的脂肪酸合成酶 (FASN) 抑制剂。C75 抑制前列腺癌细胞 PC3 的 IC50 值为 35 μM。C75 是有效的 CPT1A 激活剂。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 脂肪酸合成酶(FAS)
• 参考文献:

  [1]. Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560.

  [2]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.

  [3]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7.

  [4]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.

  [5]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

(-)-反式-C75物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 432.1±45.0 °C at 760 mmHg
• 分子式: C₁₄H₂₂O₄
• 分子量: 254.32
• 闪点: 159.2±22.2 °C
• 精确质量: 254.151810
• PSA: 63.60000
• LogP: 3.65
• InChIKey: VCWLZDVWHQVAJU-NWDGAFQWSA-N
• SMILES: C=C1C(=O)OC(CCCCCCCC)C1C(=O)O
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.489
• 储存条件: -20°C，密闭，干燥

(-)-反式-C75靶点实验

查看更多实验

实验名称：Antimicrobial activity against Staphylococcus aureus 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL888104

实验名称：Antimicrobial activity against Moraxella catarrhalis ATCC 25238 来源：ChEMBL 靶标：Moraxella catarrhalis External Id：CHEMBL888105

实验名称：Antimicrobial activity against Haemophilus influenzae IID983 来源：ChEMBL 靶标：Haemophilus influenzae External Id：CHEMBL888106

实验名称：Antimicrobial activity against Bacteroides fragilis GAI5560 来源：ChEMBL 靶标：Bacteroides fragilis External Id：CHEMBL888107

实验名称：Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL4017572

实验名称：Antiproliferative activity against fibroblasts (unknown origin) after 72 hrs by MTT a... 来源：ChEMBL 靶标：Fibroblast External Id：CHEMBL4017573

实验名称：Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：MIA PaCa-2 External Id：CHEMBL4017570

实验名称：Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL4017571

实验名称：Inhibition of type1 FAS in HepG2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL888103

实验名称：Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL4017568

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(-)-反式-C75英文别名

• (2S,3R)-4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
• (2S,3R)-4-methylidene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
• (2S,3R)-4-Methylene-2-octyl-5-oxotetrahydro-3-furancarboxylic acid