Tanimilast

Modify Date: 2024-01-07 16:18:55

Tanimilast structure	Common Name	Tanimilast
	CAS Number	1239278-59-1	Molecular Weight	687.54
	Density	1.5±0.1 g/cm3	Boiling Point	811.5±75.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₃₀Cl₂F₂N₂O₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	444.6±37.1 °C

Use of Tanimilast

Tanimilast (CHF-6001) is a novel highly potent and selective phosphodiesterase 4 inhibitor(IC50=0.026 ± 0.006 nM) with robust anti-inflammatory activity and suitable for topical pulmonary administration.Tanimilast is used for the research of obstructive lung diseases[1].

Name	CHF-6001
Synonym	More Synonyms

Description	Tanimilast (CHF-6001) is a novel highly potent and selective phosphodiesterase 4 inhibitor(IC50=0.026 ± 0.006 nM) with robust anti-inflammatory activity and suitable for topical pulmonary administration.Tanimilast is used for the research of obstructive lung diseases[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
References	[1]. Moretto N, Caruso P, Bosco R, Marchini G, Pastore F, Armani E, Amari G, Rizzi A, Ghidini E, De Fanti R, Capaldi C, Carzaniga L, Hirsch E, Buccellati C, Sala A, Carnini C, Patacchini R, Delcanale M, Civelli M, Villetti G, Facchinetti F. CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67.

Density	1.5±0.1 g/cm3
Boiling Point	811.5±75.0 °C at 760 mmHg
Molecular Formula	C₃₀H₃₀Cl₂F₂N₂O₈S
Molecular Weight	687.54
Flash Point	444.6±37.1 °C
Exact Mass	686.106812
LogP	4.43
Vapour Pressure	0.0±2.9 mmHg at 25°C
Index of Refraction	1.631

(1S)-1-[3-(Cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-4-pyridinyl)ethyl 3-(cyclopropylmethoxy)-4-[(methylsulfonyl)amino]benzoate

CHF-6001

0984EU6E2F

Benzoic acid, 3-(cyclopropylmethoxy)-4-[(methylsulfonyl)amino]-, (1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-4-pyridinyl)ethyl ester