VU0364572 TFA salt
Modify Date: 2024-01-10 12:09:28
VU0364572 TFA salt structure
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Common Name | VU0364572 TFA salt | ||
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| CAS Number | 1240514-89-9 | Molecular Weight | 487.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H32F3N3O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VU0364572 TFA saltVU0364572 TFA is an orally active and selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. VU0364572 TFA has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer’s Disease. VU0364572 TFA is CNS penetrant[1][3]. |
| Name | Ethyl (3R)-3-[(2-methylbenzoyl)amino]-1,4'-bipiperidine-1'-carboxylate trifluoroacetate (1:1) |
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| Synonym | More Synonyms |
| Description | VU0364572 TFA is an orally active and selective allosteric agonist of the M1 muscarinic receptor with an EC50 of 0.11 μM. VU0364572 TFA has neuroprotective potential for preventing memory impairments and reducing neuropathology in Alzheimer’s Disease. VU0364572 TFA is CNS penetrant[1][3]. |
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| Related Catalog | |
| Target |
mAChR1:0.11 μM (EC50) |
| In Vitro | VU0364572 (30 μM; 25 min) TFA 促进 striatal/NAc 切片中 KCNQ2、NR1 和 MARCKS 的磷酸化[2]。 Western Blot Analysis[2] Cell Line: Striatal/NAc slices Concentration: 30 μM Incubation Time: 25 min Result: Significantly increased the phosphorylation of KCNQ2 at T217, NR1 at S890, and MARCKS at S152/156. |
| In Vivo | VU0364572 TFA (10 mg/kg/day; oral; 4 months) TFA 在 5XFAD 转基因阿尔茨海默氏症小鼠中显示出神经保护作用。VU0364572 的半衰期为 45 分钟[1]。 Animal Model: 5XFAD transgenic Alzheimer’s mice[1] Dosage: 10 mg/kg/day Administration: In drinking water, from 2 months of age to 6 months Result: Preserved hippocampal memory. Significantly reduced levels of soluble and insoluble Aβ40,42 in the cortex and hippocampus of these animals. Significantly decreased oligomeric (oAβ) levels in the cortex. |
| References |
| Molecular Formula | C23H32F3N3O5 |
|---|---|
| Molecular Weight | 487.51 |
| Exact Mass | 487.229401 |
| Ethyl (3R)-3-[(2-methylbenzoyl)amino]-1,4'-bipiperidine-1'-carboxylate trifluoroacetate (1:1) |
| [1,4'-Bipiperidine]-1'-carboxylic acid, 3-[(2-methylbenzoyl)amino]-, ethyl ester, (3R)-, compd. with 2,2,2-trifluoroacetic acid (1:1) |