BNP-32 (human) acetate salt

Modify Date: 2025-08-25 11:38:00

BNP-32 (human) acetate salt structure	Common Name	BNP-32 (human) acetate salt
	CAS Number	124584-08-3	Molecular Weight	3464.037
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₄₃H₂₄₄N₅₀O₄₂S₄	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of BNP-32 (human) acetate salt

Nesiritide is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Sequence: Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His.

Name	nesiritide
Synonym	More Synonyms

Description	Nesiritide is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively. Sequence: Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Peptides
Target	Kd: 7.3 Pm (NPR-A), 13 pM (NPR-C)[1].
In Vitro	Nesiritide is an agonist of natriuretic peptide receptor (NPR), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively[1]. ProBNP1-108 stimulates guanylyl cyclase-A (GC-A) to near-maximum activities but is 13-fold less potent than Nesiritide (BNP1-32). ProBNP1-108 binds human GC-A 35-fold less tightly than Nesiritide. Neither proBNP1–108 nor Nesiritide activates GC-B. The natriuretic peptide clearance receptor binds proBNP1-108 3-fold less tightly than Nesiritide. The half time for degradation of proBNP1-108 by human kidney membranes is 2.7-fold longer than for Nesiritide, and the time required for complete degradation is 6-fold longer. Nesiritide and proBNP1-108 are best fitted by first- and second-order exponential decay models, respectively[2].
References	[1]. Koller KJ, et al. Molecular biology of the natriuretic peptides and their receptors. Circulation. 1992 Oct;86(4):1081-8. [2]. Dickey DM, et al. ProBNP(1-108) is resistant to degradation and activates guanylyl cyclase-A with reduced potency. Clin Chem. 2011 Sep;57(9):1272-8.

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₄₃H₂₄₄N₅₀O₄₂S₄
Molecular Weight	3464.037
Exact Mass	3461.737793
PSA	1613.94000
LogP	-16.34
Index of Refraction	1.679
Storage condition	-20°C

BNP-32 (human) acetate salt MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

Different Susceptibility of B-Type Natriuretic Peptide (BNP) and BNP Precursor (proBNP) to Cleavage by Neprilysin: The N-Terminal Part Does Matter.

Clin. Chem. 62 , 617-22, (2016)

Protease neprilysin is known to be responsible for the degradation of natriuretic peptides. A recent heart failure (HF) drug, LCZ696 (Entresto(TM)), that combines a neprilysin inhibitor and an angiote...

Nesiritide

NESIRITIDE ACETATE

RS 45041-190 hydrochloride