7-oxo Staurosporine
Modify Date: 2024-01-02 12:26:07
7-oxo Staurosporine structure
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Common Name | 7-oxo Staurosporine | ||
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| CAS Number | 125035-83-8 | Molecular Weight | 480.51500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H24N4O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of 7-oxo Staurosporine7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway[1][2]. |
| Name | (2R,3R,4S,6S)-3-Methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaene-16,18-dione |
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| Description | 7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway[1][2]. |
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| Related Catalog | |
| In Vitro | 7-Oxostaurosporine (50 nM, 24 h)可以导致 CHO 细胞中质膜鞘磷脂增加，但不会改变神经酰胺含量[1]。 |
| In Vivo | 7-Oxostaurosporin（6 mg/kg，每天一次，静脉注射）显着降低肿瘤生长，肿瘤生长抑制（TGI）为 56.1%，对体重无明显影响[2]。 |
| References |
| Molecular Formula | C28H24N4O4 |
|---|---|
| Molecular Weight | 480.51500 |
| Exact Mass | 480.18000 |
| PSA | 90.01000 |
| LogP | 4.39550 |
| RIDADR | NONH for all modes of transport |
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