JNJ 41876666
Modify Date: 2024-04-06 00:24:28
JNJ 41876666 structure
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Common Name | JNJ 41876666 | ||
|---|---|---|---|---|
| CAS Number | 1259026-14-6 | Molecular Weight | 503.873 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H20ClF6N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JNJ 41876666A potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM, ; exhibits minimal effect on the enzyme activity of CYP isoforms 3A4, 1A2, 2D6, 2C9, and 2C19 (IC50>10 uM); completely prevents icilin-induced WDS at an oral dose of 10 mg/kg, exhibits potent in vitro functional activity and robust oral efficacy in an inflammatory model of neuropathic pain at relatively low plasma levels; also reduces proliferation rates and proliferative fraction in prostate cancer cells. |
| Name | JNJ 41876666 |
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| Description | A potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM, ; exhibits minimal effect on the enzyme activity of CYP isoforms 3A4, 1A2, 2D6, 2C9, and 2C19 (IC50>10 uM); completely prevents icilin-induced WDS at an oral dose of 10 mg/kg, exhibits potent in vitro functional activity and robust oral efficacy in an inflammatory model of neuropathic pain at relatively low plasma levels; also reduces proliferation rates and proliferative fraction in prostate cancer cells. |
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| References | References 1. Valero ML, et al. PLoS One. 2012;7(12):e51825. 2. Parks DJ, et al. J Med Chem. 2011 Jan 13;54(1):233-47. View Related Products by Target TRP Channel |
| Molecular Formula | C23H20ClF6N3O |
|---|---|
| Molecular Weight | 503.873 |