1259026-14-6
1259026-14-6 structure
- Name: JNJ 41876666
- Chemical Name: JNJ 41876666
- CAS Number: 1259026-14-6
- Molecular Formula: C23H20ClF6N3O
- Molecular Weight: 503.873
- Create Date: 2020-01-20 12:12:57
- Modify Date: 2024-04-06 00:24:28
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A potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM, ; exhibits minimal effect on the enzyme activity of CYP isoforms 3A4, 1A2, 2D6, 2C9, and 2C19 (IC50>10 uM); completely prevents icilin-induced WDS at an oral dose of 10 mg/kg, exhibits potent in vitro functional activity and robust oral efficacy in an inflammatory model of neuropathic pain at relatively low plasma levels; also reduces proliferation rates and proliferative fraction in prostate cancer cells.
| Name | JNJ 41876666 |
|---|
| Description | A potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM, ; exhibits minimal effect on the enzyme activity of CYP isoforms 3A4, 1A2, 2D6, 2C9, and 2C19 (IC50>10 uM); completely prevents icilin-induced WDS at an oral dose of 10 mg/kg, exhibits potent in vitro functional activity and robust oral efficacy in an inflammatory model of neuropathic pain at relatively low plasma levels; also reduces proliferation rates and proliferative fraction in prostate cancer cells. |
|---|---|
| References | References 1. Valero ML, et al. PLoS One. 2012;7(12):e51825. 2. Parks DJ, et al. J Med Chem. 2011 Jan 13;54(1):233-47. View Related Products by Target TRP Channel |
| Molecular Formula | C23H20ClF6N3O |
|---|---|
| Molecular Weight | 503.873 |