Aripiprazole lauroxil
Modify Date: 2024-01-06 23:05:30
Aripiprazole lauroxil structure
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Common Name | Aripiprazole lauroxil | ||
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| CAS Number | 1259305-29-7 | Molecular Weight | 660.71400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C36H51Cl2N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Aripiprazole lauroxilAripiprazole lauroxil, an N-acyloxymethyl prodrug of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity[1]. |
| Name | [7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-2-oxo-3,4-dihydroquinolin-1-yl]methyl dodecanoate |
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| Synonym | More Synonyms |
| Description | Aripiprazole lauroxil, an N-acyloxymethyl prodrug of aripiprazole, is a Long-acting injectable (LAI) typical antipsychotic for schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity[1]. |
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| Related Catalog | |
| In Vivo | Aripiprazole lauroxil (intravenous administration; 1.87 mg/ml) bioconversion in vivo involves the formation of an intermediate, N-hydroxymethyl aripiprazole, the in vitro data indicates a high bioconversion of aripiprazole lauroxil, thus, the concentration of N-hydroxymethyl aripiprazole observed in the animals dosed with aripiprazole lauroxil is surprisingly high[1]. Animal Model: Female Sprague Dawley rats[1] Dosage: 1.87 mg/ml Administration: Blood samples is taken at 5, 15, 30 min and 1, 2, 4, 6, 8 and 24 h after administration Result: Exhibits an clearance: 0.32 ± 0.11 L/h/kg. |
| References |
| Molecular Formula | C36H51Cl2N3O4 |
|---|---|
| Molecular Weight | 660.71400 |
| Exact Mass | 659.32600 |
| PSA | 62.32000 |
| LogP | 8.74330 |
| Storage condition | 2~8°C |
| Hazard Codes | Xi |
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| Aripiprazole lauroxil (USAN) |
| Aripiprazole lauroxil |
| UNII-B786J7A343 |
| (7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-3,4-dihydroquinolin-1(2H)-yl)methyl dodecanoate |
| RDC-3317 |