JTZ-951 hydrochloride

Modify Date: 2024-04-08 18:04:34

JTZ-951 hydrochloride Structure
JTZ-951 hydrochloride structure
 Common Name JTZ-951 hydrochloride
CAS Number 1262131-60-1 Molecular Weight 376.797
Density N/A Boiling Point N/A
Molecular Formula C17H17ClN4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of JTZ-951 hydrochloride


A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2; increases EPO release from Hep3B cells with EC50 of 5.7 uM, increases hemoglobin levels in rats. Anemia Phase 2 Clinical

 Names

Name JTZ-951 hydrochloride

 JTZ-951 hydrochloride Biological Activity

Description A novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2; increases EPO release from Hep3B cells with EC50 of 5.7 uM, increases hemoglobin levels in rats. Anemia Phase 2 Clinical
References References 1. Yosuke Ogoshi, et al. ACS Med. Chem. Lett., 2017, 8 (12), pp 1320-1325. View Related Products by Target HIF/HIF Prolyl-hydroxylase Anemia

 Chemical & Physical Properties

Molecular Formula C17H17ClN4O4
Molecular Weight 376.797
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