JTZ-951 structure
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Common Name | JTZ-951 | ||
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CAS Number | 1262132-81-9 | Molecular Weight | 340.333 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C17H16N4O4 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of JTZ-951Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM; Enarodustat has entered clinical trial for renal anemia. |
Name | enarodustat |
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Synonym | More Synonyms |
Description | Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM; Enarodustat has entered clinical trial for renal anemia. |
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Related Catalog | |
Target |
EC50: 0.22 μM (factor prolyl hydroxylase)[1] |
In Vitro | Enarodustat (JTZ-951) is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition[1]. |
In Vivo | Enarodustat (1 and 3 mg/kg, p.o.) increases hemoglobin levels in a dose-dependent manner with daily oral dosing in rats[1]. |
References |
Density | 1.5±0.1 g/cm3 |
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Molecular Formula | C17H16N4O4 |
Molecular Weight | 340.333 |
Exact Mass | 340.117157 |
LogP | 1.60 |
Index of Refraction | 1.690 |
JSK7TUA223 |
enarodustat |
Glycine, N-[[7-hydroxy-5-(2-phenylethyl)[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl]- |
N-{[7-Hydroxy-5-(2-phenylethyl)[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}glycine |