SOMG-833
Modify Date: 2025-09-18 19:18:02
SOMG-833 structure
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Common Name | SOMG-833 | ||
|---|---|---|---|---|
| CAS Number | 1268264-10-3 | Molecular Weight | 445.446 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H22F3N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SOMG-833A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo. |
| Name | SOMG-833 |
|---|
| Description | A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo. |
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| References | References 1. Zhang HT, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):36-45. View Related Products by Target c-Met (HGFR) |
| Molecular Formula | C22H22F3N5O2 |
|---|---|
| Molecular Weight | 445.446 |
| InChIKey | JIYPGFPFAVEPFX-UHFFFAOYSA-N |
| SMILES | CN1CCN(c2cnc3cc(C(F)(F)F)cc(NCc4cccc([N+](=O)[O-])c4)c3c2)CC1 |